Proliferative activity of meningiomas has been studied using AgNORs. The results have been compared to clinical and histological variables. Ninety-nine totally removed meningiomas, sixty-nine cranial and thirty spinal, were included in the study. Meningiomas were classified as benign, atypical and anaplastic according to Mahmood's modified WHO histological grading system. AgNOR were assessed by Crocker's method in 92 cases. The benign tumors made up 89% of the cases included in this series. The mean follow-up was 86 months. There were nine recurrences, 70% of them from histologically benign tumors. AgNORs were higher in primary tumors with subsequent recurrence and also higher in the recurrences than in primary tumors, but significant differences were not stablished. Significant differences in AgNORs were found between cranial and spinal meningiomas (p = 0.01) as well as between highly recurrent tumors and the other histological types (p = 0.04). In the same way AgNORs correlated to necrosis (p = 0.003). In conclusion, AgNORs could be a useful index of proliferative activity in meningiomas because of its relationship with necrosis and histological types with worse prognosis. AgNORs might be a valuable complement to classical histology in these tumors.
|Journal||Electronic Journal of Pathology and Histology|
|Publication status||Published - 1 Dec 1996|
- Argyrophilic nucleolar organizer region (AgNOR)