Validation of the Spanish version of Addenbrooke's Cognitive Examination III for diagnosing dementia

J. A. Matias-Guiu, R. Fernández de Bobadilla, G. Escudero, J. Pérez-Pérez, A. Cortés, E. Morenas-Rodríguez, M. Valles-Salgado, T. Moreno-Ramos, J. Kulisevsky, J. Matías-Guiu

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54 Citations (Scopus)


© 2014 Sociedad Española de Neurología. Introduction: Addenbrooke's Cognitive Examination is a screening test used to diagnose dementia. The third edition of this test (ACE-III) was recently developed. The aim of this study was to translate and validate the ACE-III in Spanish. Methods: The ACE-III was translated and adapted to Spanish. It was then administered to a group of healthy subjects as well as a group of patients with different types of mild dementia treated in 2 hospitals in Spain. Results: Internal reliability (Cronbach's alpha = 0.927), inter-rater reliability (intraclass correlation coefficient = 0.976) and test-retest reliability (kappa 0.995) were excellent. Age (r = -0.512) and education (r = 0.659) showed a significant correlation with total test scores. The diagnostic accuracy of ACE-III was higher than that of the Mini-Mental State Examination, particularly for the group with the highest educational level. Researchers obtained normative data and cut-off points for the diagnosis of dementia. Conclusions: The Spanish version of the ACE-III is a reliable and valid test for diagnosing dementia. Its diagnostic accuracy is high, especially in patients with a higher level of education.
Original languageEnglish
Pages (from-to)545-551
Issue number9
Publication statusPublished - 1 Jan 2015


  • Addenbrooke's Cognitive Examination
  • Alzheimer disease
  • Cognitive screening
  • Dementia
  • Frontotemporal dementia
  • Neuropsychological assessment


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