Utility of early imaging of myocardial innervation scintigraphy in the diagnosis of Lewy Body Dementia

V. Camacho; M. Estorch; M. Marquié; A. Domènech; A. Flotats; A. Fernández; J. Duch; L. L. Geraldo; J. Deportos; C. Artigas; A. Lleó; I. Carrió

doi:10.1016/j.remn.2012.03.012

Utility of early imaging of myocardial innervation scintigraphy in the diagnosis of Lewy Body Dementia

V. Camacho, M. Estorch, M. Marquié, A. Domènech, A. Flotats, A. Fernández, J. Duch, L. L. Geraldo, J. Deportos, C. Artigas, A. Lleó, I. Carrió

Department of Medicine

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5 Citations (Scopus)

Abstract

The importance of accurate and early diagnosis of dementia with Lewy bodies (DLB) lies in its pharmacological management. Delayed imaging of cardiac 123I-MIBG scintigraphy allows differentiation between DLB and other neurodegenerative diseases with cognitive impairment.The aim of this study was to assess the utility of early imaging of cardiac 123I-MIBG scintigraphy for differentiating DLB from others neurodegenerative disease with cognitive impairment. Material and methods: We assess retrospectively 106 patients (51 men, mean age 78 years) with cognitive impairment that underwent a cardiac 123I-MIBG study. Planar images were acquired in anterior view of the thorax 15min (early) and 4h (delayed) after tracer administration. The heart-to-mediastinum ratios (HMR) at 15m (HMR15m) and at 4h (HMR4h) were obtained. Results: After four years, 52 patients were diagnosed of DLB.HMR15m and HMR4h were significantly inferior in DLB respect to the others neurodegenerative diseases (1,27±0,15 vs 1,76±0,15,p<0,05) and (1,14±0,13 vs 1,68±0,19,p<0.01), respectively. The ROC analysis showed a HMR15m cut off point of 1.56 to differentiated DLB from the other dementias with a sensitivity and a specificity of 98%. Conclusions: Early imaging of cardiac 123I-MIBG scintigraphy can help to differentiate DLB from other neurodegenerative diseases with cognitive impairment. © 2012 Elsevier España, S.L. y SEMNIM.

Original language	English
Pages (from-to)	77-80
Journal	Revista Espanola de Medicina Nuclear e Imagen Molecular
Volume	32
Issue number	2
DOIs	https://doi.org/10.1016/j.remn.2012.03.012
Publication status	Published - 1 Mar 2013

Keywords

123 I-MIBG
Cardiac MIBG scintigraphy
Dementia with Lewy Bodies
Early imaging

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10.1016/j.remn.2012.03.012

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Camacho, V., Estorch, M., Marquié, M., Domènech, A., Flotats, A., Fernández, A., Duch, J., Geraldo, L. L., Deportos, J., Artigas, C., Lleó, A., & Carrió, I. (2013). Utility of early imaging of myocardial innervation scintigraphy in the diagnosis of Lewy Body Dementia. Revista Espanola de Medicina Nuclear e Imagen Molecular, 32(2), 77-80. https://doi.org/10.1016/j.remn.2012.03.012

Camacho, V. ; Estorch, M. ; Marquié, M. ; Domènech, A. ; Flotats, A. ; Fernández, A. ; Duch, J. ; Geraldo, L. L. ; Deportos, J. ; Artigas, C. ; Lleó, A. ; Carrió, I. / Utility of early imaging of myocardial innervation scintigraphy in the diagnosis of Lewy Body Dementia. In: Revista Espanola de Medicina Nuclear e Imagen Molecular. 2013 ; Vol. 32, No. 2. pp. 77-80.

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title = "Utility of early imaging of myocardial innervation scintigraphy in the diagnosis of Lewy Body Dementia",

abstract = "The importance of accurate and early diagnosis of dementia with Lewy bodies (DLB) lies in its pharmacological management. Delayed imaging of cardiac 123I-MIBG scintigraphy allows differentiation between DLB and other neurodegenerative diseases with cognitive impairment.The aim of this study was to assess the utility of early imaging of cardiac 123I-MIBG scintigraphy for differentiating DLB from others neurodegenerative disease with cognitive impairment. Material and methods: We assess retrospectively 106 patients (51 men, mean age 78 years) with cognitive impairment that underwent a cardiac 123I-MIBG study. Planar images were acquired in anterior view of the thorax 15min (early) and 4h (delayed) after tracer administration. The heart-to-mediastinum ratios (HMR) at 15m (HMR15m) and at 4h (HMR4h) were obtained. Results: After four years, 52 patients were diagnosed of DLB.HMR15m and HMR4h were significantly inferior in DLB respect to the others neurodegenerative diseases (1,27±0,15 vs 1,76±0,15,p<0,05) and (1,14±0,13 vs 1,68±0,19,p<0.01), respectively. The ROC analysis showed a HMR15m cut off point of 1.56 to differentiated DLB from the other dementias with a sensitivity and a specificity of 98%. Conclusions: Early imaging of cardiac 123I-MIBG scintigraphy can help to differentiate DLB from other neurodegenerative diseases with cognitive impairment. {\textcopyright} 2012 Elsevier Espa{\~n}a, S.L. y SEMNIM.",

keywords = "123 I-MIBG, Cardiac MIBG scintigraphy, Dementia with Lewy Bodies, Early imaging",

author = "V. Camacho and M. Estorch and M. Marqui{\'e} and A. Dom{\`e}nech and A. Flotats and A. Fern{\'a}ndez and J. Duch and Geraldo, {L. L.} and J. Deportos and C. Artigas and A. Lle{\'o} and I. Carri{\'o}",

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Camacho, V, Estorch, M, Marquié, M, Domènech, A, Flotats, A, Fernández, A, Duch, J, Geraldo, LL, Deportos, J, Artigas, C, Lleó, A & Carrió, I 2013, 'Utility of early imaging of myocardial innervation scintigraphy in the diagnosis of Lewy Body Dementia', Revista Espanola de Medicina Nuclear e Imagen Molecular, vol. 32, no. 2, pp. 77-80. https://doi.org/10.1016/j.remn.2012.03.012

Utility of early imaging of myocardial innervation scintigraphy in the diagnosis of Lewy Body Dementia. / Camacho, V.; Estorch, M.; Marquié, M.; Domènech, A.; Flotats, A.; Fernández, A.; Duch, J.; Geraldo, L. L.; Deportos, J.; Artigas, C.; Lleó, A.; Carrió, I.

In: Revista Espanola de Medicina Nuclear e Imagen Molecular, Vol. 32, No. 2, 01.03.2013, p. 77-80.

Research output: Contribution to journal › Article › Research › peer-review

TY - JOUR

T1 - Utility of early imaging of myocardial innervation scintigraphy in the diagnosis of Lewy Body Dementia

AU - Camacho, V.

AU - Estorch, M.

AU - Marquié, M.

AU - Domènech, A.

AU - Flotats, A.

AU - Fernández, A.

AU - Duch, J.

AU - Geraldo, L. L.

AU - Deportos, J.

AU - Artigas, C.

AU - Lleó, A.

AU - Carrió, I.

PY - 2013/3/1

Y1 - 2013/3/1

N2 - The importance of accurate and early diagnosis of dementia with Lewy bodies (DLB) lies in its pharmacological management. Delayed imaging of cardiac 123I-MIBG scintigraphy allows differentiation between DLB and other neurodegenerative diseases with cognitive impairment.The aim of this study was to assess the utility of early imaging of cardiac 123I-MIBG scintigraphy for differentiating DLB from others neurodegenerative disease with cognitive impairment. Material and methods: We assess retrospectively 106 patients (51 men, mean age 78 years) with cognitive impairment that underwent a cardiac 123I-MIBG study. Planar images were acquired in anterior view of the thorax 15min (early) and 4h (delayed) after tracer administration. The heart-to-mediastinum ratios (HMR) at 15m (HMR15m) and at 4h (HMR4h) were obtained. Results: After four years, 52 patients were diagnosed of DLB.HMR15m and HMR4h were significantly inferior in DLB respect to the others neurodegenerative diseases (1,27±0,15 vs 1,76±0,15,p<0,05) and (1,14±0,13 vs 1,68±0,19,p<0.01), respectively. The ROC analysis showed a HMR15m cut off point of 1.56 to differentiated DLB from the other dementias with a sensitivity and a specificity of 98%. Conclusions: Early imaging of cardiac 123I-MIBG scintigraphy can help to differentiate DLB from other neurodegenerative diseases with cognitive impairment. © 2012 Elsevier España, S.L. y SEMNIM.

AB - The importance of accurate and early diagnosis of dementia with Lewy bodies (DLB) lies in its pharmacological management. Delayed imaging of cardiac 123I-MIBG scintigraphy allows differentiation between DLB and other neurodegenerative diseases with cognitive impairment.The aim of this study was to assess the utility of early imaging of cardiac 123I-MIBG scintigraphy for differentiating DLB from others neurodegenerative disease with cognitive impairment. Material and methods: We assess retrospectively 106 patients (51 men, mean age 78 years) with cognitive impairment that underwent a cardiac 123I-MIBG study. Planar images were acquired in anterior view of the thorax 15min (early) and 4h (delayed) after tracer administration. The heart-to-mediastinum ratios (HMR) at 15m (HMR15m) and at 4h (HMR4h) were obtained. Results: After four years, 52 patients were diagnosed of DLB.HMR15m and HMR4h were significantly inferior in DLB respect to the others neurodegenerative diseases (1,27±0,15 vs 1,76±0,15,p<0,05) and (1,14±0,13 vs 1,68±0,19,p<0.01), respectively. The ROC analysis showed a HMR15m cut off point of 1.56 to differentiated DLB from the other dementias with a sensitivity and a specificity of 98%. Conclusions: Early imaging of cardiac 123I-MIBG scintigraphy can help to differentiate DLB from other neurodegenerative diseases with cognitive impairment. © 2012 Elsevier España, S.L. y SEMNIM.

KW - 123 I-MIBG

KW - Cardiac MIBG scintigraphy

KW - Dementia with Lewy Bodies

KW - Early imaging

U2 - 10.1016/j.remn.2012.03.012

DO - 10.1016/j.remn.2012.03.012

M3 - Article

VL - 32

SP - 77

EP - 80

IS - 2

ER -

Utility of early imaging of myocardial innervation scintigraphy in the diagnosis of Lewy Body Dementia

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Keywords

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