TY - JOUR
T1 - Utility of early imaging of myocardial innervation scintigraphy in the diagnosis of Lewy Body Dementia
AU - Camacho, V.
AU - Estorch, M.
AU - Marquié, M.
AU - Domènech, A.
AU - Flotats, A.
AU - Fernández, A.
AU - Duch, J.
AU - Geraldo, L. L.
AU - Deportos, J.
AU - Artigas, C.
AU - Lleó, A.
AU - Carrió, I.
PY - 2013/3/1
Y1 - 2013/3/1
N2 - The importance of accurate and early diagnosis of dementia with Lewy bodies (DLB) lies in its pharmacological management. Delayed imaging of cardiac 123I-MIBG scintigraphy allows differentiation between DLB and other neurodegenerative diseases with cognitive impairment.The aim of this study was to assess the utility of early imaging of cardiac 123I-MIBG scintigraphy for differentiating DLB from others neurodegenerative disease with cognitive impairment. Material and methods: We assess retrospectively 106 patients (51 men, mean age 78 years) with cognitive impairment that underwent a cardiac 123I-MIBG study. Planar images were acquired in anterior view of the thorax 15min (early) and 4h (delayed) after tracer administration. The heart-to-mediastinum ratios (HMR) at 15m (HMR15m) and at 4h (HMR4h) were obtained. Results: After four years, 52 patients were diagnosed of DLB.HMR15m and HMR4h were significantly inferior in DLB respect to the others neurodegenerative diseases (1,27±0,15 vs 1,76±0,15,p<0,05) and (1,14±0,13 vs 1,68±0,19,p<0.01), respectively. The ROC analysis showed a HMR15m cut off point of 1.56 to differentiated DLB from the other dementias with a sensitivity and a specificity of 98%. Conclusions: Early imaging of cardiac 123I-MIBG scintigraphy can help to differentiate DLB from other neurodegenerative diseases with cognitive impairment. © 2012 Elsevier España, S.L. y SEMNIM.
AB - The importance of accurate and early diagnosis of dementia with Lewy bodies (DLB) lies in its pharmacological management. Delayed imaging of cardiac 123I-MIBG scintigraphy allows differentiation between DLB and other neurodegenerative diseases with cognitive impairment.The aim of this study was to assess the utility of early imaging of cardiac 123I-MIBG scintigraphy for differentiating DLB from others neurodegenerative disease with cognitive impairment. Material and methods: We assess retrospectively 106 patients (51 men, mean age 78 years) with cognitive impairment that underwent a cardiac 123I-MIBG study. Planar images were acquired in anterior view of the thorax 15min (early) and 4h (delayed) after tracer administration. The heart-to-mediastinum ratios (HMR) at 15m (HMR15m) and at 4h (HMR4h) were obtained. Results: After four years, 52 patients were diagnosed of DLB.HMR15m and HMR4h were significantly inferior in DLB respect to the others neurodegenerative diseases (1,27±0,15 vs 1,76±0,15,p<0,05) and (1,14±0,13 vs 1,68±0,19,p<0.01), respectively. The ROC analysis showed a HMR15m cut off point of 1.56 to differentiated DLB from the other dementias with a sensitivity and a specificity of 98%. Conclusions: Early imaging of cardiac 123I-MIBG scintigraphy can help to differentiate DLB from other neurodegenerative diseases with cognitive impairment. © 2012 Elsevier España, S.L. y SEMNIM.
KW - 123 I-MIBG
KW - Cardiac MIBG scintigraphy
KW - Dementia with Lewy Bodies
KW - Early imaging
U2 - 10.1016/j.remn.2012.03.012
DO - 10.1016/j.remn.2012.03.012
M3 - Article
VL - 32
SP - 77
EP - 80
JO - Revista Espanola de Medicina Nuclear e Imagen Molecular
JF - Revista Espanola de Medicina Nuclear e Imagen Molecular
SN - 2253-654X
IS - 2
ER -