Utility of anti-Hu antibodies in the diagnosis of paraneoplastic sensory neuropathy

Jose Luis Molinuevo, Francesc Graus, Carmen Serrano, Ramón Reñe, Antonio Guerrero, Isabel Illa

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141 Citations (Scopus)


Anti-Hu antibodies (Hu-Abs) were positive in 40 patients with paraneoplastic sensory neuropathy (PSN) and in 1 patient with idiopathic sensory neuropathy in a series of 126 patients who presented with clinical features suggestive of PSN. The specificity of Hu-Abs was 99% and the sensitivity was 82%. Nine (18%) PSN patients were Hu-Ab-negative, and their sera did not harbor other specific anti-neuronal or anti-ganglioside antibodies. Small cell lung carcinoma (SCLC) was the leading neoplasm in the Hu-Ab-positive (79%) and Hu-Ab-negative (44%) groups. This study confirms the value of Hu-Abs for the diagnosis of PSN and SCLC and also emphasizes that in patients with possible PSN, the absence of Hu-Abs does not exclude cancer, particularly in those patients with risk factors for SCLC.
Original languageEnglish
Pages (from-to)976-980
JournalAnnals of Neurology
Issue number6
Publication statusPublished - 1 Jan 1998


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