Utility of anti-Hu antibodies in the diagnosis of paraneoplastic sensory neuropathy

Jose Luis Molinuevo; Francesc Graus; Carmen Serrano; Ramón Reñe; Antonio Guerrero; Isabel Illa

doi:10.1002/ana.410440620

Utility of anti-Hu antibodies in the diagnosis of paraneoplastic sensory neuropathy

Jose Luis Molinuevo, Francesc Graus, Carmen Serrano, Ramón Reñe, Antonio Guerrero, Isabel Illa

Department of Medicine

Research output: Contribution to journal › Article › Research › peer-review

135 Citations (Scopus)

Abstract

Anti-Hu antibodies (Hu-Abs) were positive in 40 patients with paraneoplastic sensory neuropathy (PSN) and in 1 patient with idiopathic sensory neuropathy in a series of 126 patients who presented with clinical features suggestive of PSN. The specificity of Hu-Abs was 99% and the sensitivity was 82%. Nine (18%) PSN patients were Hu-Ab-negative, and their sera did not harbor other specific anti-neuronal or anti-ganglioside antibodies. Small cell lung carcinoma (SCLC) was the leading neoplasm in the Hu-Ab-positive (79%) and Hu-Ab-negative (44%) groups. This study confirms the value of Hu-Abs for the diagnosis of PSN and SCLC and also emphasizes that in patients with possible PSN, the absence of Hu-Abs does not exclude cancer, particularly in those patients with risk factors for SCLC.

Original language	English
Pages (from-to)	976-980
Journal	Annals of Neurology
Volume	44
Issue number	6
DOIs	https://doi.org/10.1002/ana.410440620
Publication status	Published - 1 Jan 1998

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Molinuevo, J. L., Graus, F., Serrano, C., Reñe, R., Guerrero, A., & Illa, I. (1998). Utility of anti-Hu antibodies in the diagnosis of paraneoplastic sensory neuropathy. Annals of Neurology, 44(6), 976-980. https://doi.org/10.1002/ana.410440620

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