Using direct oral anticoagulants in patients with atrial fibrillation: Assessment, monitoring and treatment reversal

Antoni Martínez-Rubio, Mario Diaz Nuila Alcazar, Anna Soria Cadena, Roger Martínez-Torrecilla

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Abstract

© Radcliffe Cardiology 2016. It is essential to prevent thromboembolic events in atrial fibrillation. The risks of thromboembolic and haemorrhagic events must be carefully assessed and weighed against one another, both in routine situations and in relation to invasive procedures. Vitamin K antagonists, until recently the first-line treatment for prophylaxis against thromboembolic events in patients with atrial fibrillation, have various drawbacks. Direct-acting oral anticoagulants overcome these limitations and are efficacious and safe. The recent developments of tests to monitor anticoagulant levels, and of target-specific reversal agents for these newer drugs, has facilitated their use in several situations, including emergencies. For these reasons, the European Society of Cardiology and other scientific societies now recommend direct-acting oral anticoagulants as first-line treatment for preventing thromboembolic events in atrial fibrillation.
Original languageEnglish
Pages (from-to)118-122
JournalEuropean Cardiology Review
Volume11
Issue number2
DOIs
Publication statusPublished - 1 Jan 2016

Keywords

  • Atrial fibrillation
  • Coagulation monitoring
  • Direct-acting oral anticoagulants
  • Periprocedural management
  • Reversal agents
  • Risk stratification

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