TY - JOUR
T1 - Usefulness of peripapillary nerve fiber layer thickness assessed by optical coherence tomography as a biomarker for Alzheimer’s disease
AU - Sánchez, Domingo
AU - Castilla-Marti, Miguel
AU - Rodríguez-Gómez, Octavio
AU - Valero, Sergi
AU - Piferrer, Albert
AU - Martínez, Gabriel
AU - Martínez, Joan
AU - Serra, Judit
AU - Moreno-Grau, Sonia
AU - Hernández-Olasagarre, Begoña
AU - De Rojas, Itziar
AU - Hernández, Isabel
AU - Abdelnour, Carla
AU - Rosende-Roca, Maitée
AU - Vargas, Liliana
AU - Mauleón, Ana
AU - Santos-Santos, Miguel A.
AU - Alegret, Montserrat
AU - Ortega, Gemma
AU - Espinosa, Ana
AU - Pérez-Cordón, Alba
AU - Sanabria, Ángela
AU - Ciudin, Andrea
AU - Simó, Rafael
AU - Hernández, Cristina
AU - Villaoslada, Pablo
AU - Ruiz, Agustín
AU - Tàrraga, Lluís
AU - Boada, Mercè
PY - 2018/12/1
Y1 - 2018/12/1
N2 - © 2018, The Author(s). The use of optical coherence tomography (OCT) has been suggested as a potential biomarker for Alzheimer’s Disease based on previously reported thinning of the retinal nerve fiber layer (RNFL) in Alzheimer’s disease’s (AD) and Mild Cognitive Impairment (MCI). However, other studies have not shown such results. 930 individuals (414 cognitively healthy individuals, 192 probable amnestic MCI and 324 probable AD) attending a memory clinic were consecutively included and underwent spectral domain OCT (Maestro, Topcon) examinations to assess differences in peripapillary RNFL thickness, using a design of high ecological validity. Adjustment by age, education, sex and OCT image quality was performed. We found a non-significant decrease in mean RNFL thickness as follows: control group: 100,20 ± 14,60 µm, MCI group: 98,54 ± 14,43 µm and AD group: 96,61 ± 15,27 µm. The multivariate adjusted analysis revealed no significant differences in mean overall (p = 0.352), temporal (p = 0,119), nasal (p = 0,151), superior (p = 0,435) or inferior (p = 0,825) quadrants between AD, MCI and control groups. These results do not support the usefulness of peripapillary RNFL analysis as a marker of cognitive impairment or in discriminating between cognitive groups. The analysis of other OCT measurements in other retinal areas and layers as biomarkers for AD should be tested further.
AB - © 2018, The Author(s). The use of optical coherence tomography (OCT) has been suggested as a potential biomarker for Alzheimer’s Disease based on previously reported thinning of the retinal nerve fiber layer (RNFL) in Alzheimer’s disease’s (AD) and Mild Cognitive Impairment (MCI). However, other studies have not shown such results. 930 individuals (414 cognitively healthy individuals, 192 probable amnestic MCI and 324 probable AD) attending a memory clinic were consecutively included and underwent spectral domain OCT (Maestro, Topcon) examinations to assess differences in peripapillary RNFL thickness, using a design of high ecological validity. Adjustment by age, education, sex and OCT image quality was performed. We found a non-significant decrease in mean RNFL thickness as follows: control group: 100,20 ± 14,60 µm, MCI group: 98,54 ± 14,43 µm and AD group: 96,61 ± 15,27 µm. The multivariate adjusted analysis revealed no significant differences in mean overall (p = 0.352), temporal (p = 0,119), nasal (p = 0,151), superior (p = 0,435) or inferior (p = 0,825) quadrants between AD, MCI and control groups. These results do not support the usefulness of peripapillary RNFL analysis as a marker of cognitive impairment or in discriminating between cognitive groups. The analysis of other OCT measurements in other retinal areas and layers as biomarkers for AD should be tested further.
U2 - https://doi.org/10.1038/s41598-018-34577-3
DO - https://doi.org/10.1038/s41598-018-34577-3
M3 - Article
C2 - 30397251
VL - 8
JO - Scientific Reports
JF - Scientific Reports
SN - 2045-2322
M1 - 16345
ER -