Usefulness of noninvasive methods for the study of bronchial inflammation in the control of patients with asthma

Xavier Muñoz, Victor Bustamante, José Luis Lopez-Campos, María Jesús Cruz, Esther Barreiro

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    17 Citations (Scopus)


    © 2015 S. Karger AG, Basel. Bronchial asthma is one of the most prevalent respiratory conditions. Although it is defined as an inflammatory disease, the current guidelines for both diagnosis and follow-up of patients are based only on clinical and lung function parameters. Current research is focused on finding markers that can accurately predict future risk, and on assessing the ability of these markers to guide medical treatment and thus improve prognosis. The use of noninvasive methods to study airway inflammation is gaining increasing support. The study of eosinophils in induced sputum has proved useful for the diagnosis of asthma; however, its clinical implementation is complex. Some studies have shown that the measurement of exhaled nitric oxide (FeNO) may also be useful to establish disease phenotypes and improve control. Others have found that the measurement of pH and certain markers of oxidative stress, cytokines and prostanoids in exhaled breath condensate (EBC) may also be useful as well as the measurement of the temperature of exhaled breath and the analysis of volatile organic compounds (VOCs). In conclusion, since asthma is an inflammatory disease, it seems appropriate to try to control it through the study of airway inflammation using noninvasive methods. In this regard, the analysis of induced sputum cells has proved very useful, although the clinical implementation of this technique seems difficult. Other techniques such as temperature measurement, the analysis of FeNO, the analysis of the VOCs in exhaled breath, or the study of certain biomarkers in EBC require further study in order to determine their clinical applicability.
    Original languageEnglish
    Pages (from-to)1-12
    JournalInternational Archives of Allergy and Immunology
    Issue number1
    Publication statusPublished - 1 Jan 2015


    • Eosinophils
    • Exhaled breath condensate
    • Exhaled nitric oxide
    • Induced sputum
    • Volatile organic compounds


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