Use of interferon-gamma release assays to calculate the annual risk of tuberculosis infection

Nuria Díez, Empar Giner, Irene Latorre, Alícia Lacoma, Francisco Javier Roig, Irene Mialdea, Jessica Díaz, Mar Serra-Vidal, Amparo Escribano, Jose Domínguez

    Research output: Contribution to journalArticleResearchpeer-review

    2 Citations (Scopus)

    Abstract

    Copyright © 2014 by Wolters Kluwer Health, Inc. All rights reserved. The objective was to assess the annual risk of tuberculosis infection by means of tuberculin skin testing (TST) in children, evaluating whether QuantiFERON-TB Gold In-Tube (QFN-G-IT) could improve the accuracy. On the basis of the positive TST results, the global annual incidence was estimated at 0.78%, with an increase in the prevalence from 0.64% to 1.68% in 2 years. However, QFN-G-IT was only positive in 6 of the 25 children with positive TST. The confirmation of the positive TST results by QFN-G-IT provided more accurate annual incidence estimation.
    Original languageEnglish
    Pages (from-to)219-221
    JournalJournal of Pediatric Infectious Diseases
    Volume34
    Issue number2
    DOIs
    Publication statusPublished - 1 Jan 2015

    Keywords

    • Annual risk of tuberculosis infection
    • QFN
    • Tuberculin skin tests

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