The 1,3-dipolar cycloaddition of C,N-diphenylnitrone to tert-butyl vinyl ether in the presence of several chiral Ti(IV) species which incorporate different bidentate C2-symmetrical ligands has been investigated. Several complexes have shown very efficient catalytic activity. The endo/exo selectivity of the process can be dramatically reversed in relation to the uncatalysed reaction, but low enantioselectivities up to 41% ee are found. (C) 2000 Elsevier Science Ltd.
|Publication status||Published - 5 May 2000|
Bayón, P., De March, P., Espinosa, M., Figueredo, M., & Font, J. (2000). Use of chiral Ti(IV) complexes in the cycloaddition of C,N- diphenylnitrone to tert-butyl vinyl ether. Tetrahedron Asymmetry, 11(8), 1757-1765. https://doi.org/10.1016/S0957-4166(00)00115-4