Urinary neuropilin-1: A predictive biomarker for renal outcome in lupus nephritis

Maria Teresa Torres-Salido, Mireia Sanchis, Cristina Solé, Teresa Moliné, Marta Vidal, Xavier Vidal, Anna Solà, Georgina Hotter, Josep Ordi-Ros, Josefina Cortés-Hernández

Research output: Contribution to journalArticleResearch

3 Citations (Scopus)

Abstract

© 2019 by the authors. Licensee MDPI, Basel, Switzerland. At present, Lupus Nephritis (LN) is still awaiting a biomarker to better monitor disease activity, guide clinical treatment, and predict a patient’s long-term outcome. In the last decade, novel biomarkers have been identified to monitor the disease, but none have been incorporated into clinical practice. The transmembrane receptor neuropilin-1 (NRP-1) is highly expressed by mesangial cells and its genetic deletion results in proteinuric disease and glomerulosclerosis. NRP-1 is increased in kidney biopsies of LN. In this work we were interested in determining whether urinary NRP-1 levels could be a biomarker of clinical response in LN. Our results show that patients with active LN have increased levels of urinary NRP-1. When patients were divided according to clinical response, responders displayed higher urinary and tissue NRP-1 levels at the time of renal biopsy. Areas under the receiver operating characteristic curve, comparing baseline creatinine, proteinuria, urinary NRP-1, and VEGFA protein levels, showed NRP-1 to be an independent predictor for clinical response. In addition, in vitro studies suggest that NRP-1could promote renal recovery through endothelial proliferation and migration, mesangial migration and local T cell cytotoxicity. Based on these results, NRP-1 may be used as an early prognostic biomarker in LN.
Original languageEnglish
Article number4601
JournalInternational Journal of Molecular Sciences
Volume20
DOIs
Publication statusPublished - 2 Sep 2019

Keywords

  • Clinical responder
  • Lupus nephritis
  • Neuropilin-1
  • Renal biopsy
  • Urinary biomarker

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