Urinary micafungin levels are sufficient to treat urinary tract infections caused by Candida spp.

S. Grau, S. Luque, D. Echeverría-Esnal, L. Sorlí, N. Campillo, M. Montero, F. Álvarez Lerma, V. Plasencia, J. P. Horcajada

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Abstract

© 2016 Elsevier B.V. and International Society of Chemotherapy Six cases of patients diagnosed with urinary tract infection (UTI) successfully treated with micafungin are reported. Four were infected with fluconazole-resistant Candida spp. and two (with hepatic injury) were infected with fluconazole-sensitive Candida spp. Traditionally, echinocandins have not been considered for the treatment of UTIs. However, despite its low urinary excretion rate, therapeutic drug monitoring of micafungin urinary levels could be helpful in order to achieve optimal pharmacokinetic/pharmacodynamic (PK/PD) indices for treating UTIs caused by Candida spp. resistant to fluconazole.
Original languageEnglish
Pages (from-to)212-214
JournalInternational Journal of Antimicrobial Agents
Volume48
Issue number2
DOIs
Publication statusPublished - 1 Aug 2016

Keywords

  • Candida spp
  • Fluconazole-resistant
  • Micafungin
  • Urinary tract infection

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