Unrelated cord blood Transplant. for adult patients with acutemyeloid leukemia: Higher incidence of acute graft-versus-host Dis. and lower survival inmale patients transplanted with female unrelated cord blood - A report from Eurocord, the Acute Leukemia Working Party, and the Cord Blood Comm. of the Cell. Ther. and Immunobiol. Working Party of the Europ. Group for Blood and Marrow Transplant.

Frédéric Baron*, Myriam Labopin, Annalisa Ruggeri, Mohamad Mohty, Guillermo Sanz, Noel Milpied, Andrea Bacigalupo, Alessandro Rambaldi, Francesca Bonifazi, Alberto Bosi, Jorge Sierra, Ibrahim Yakoub-Agha, Josep Maria Ribera Santasusana, Eliane Gluckman, Arnon Nagler

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

33 Citations (Scopus)

Abstract

Background: In the setting of allogeneic human leukocyte antigen (HLA)-matched bone marrow transplantation, transplanting male patients with grafts from female donors has been associated with a higher incidence of graft-versus-host disease (GVHD) and of nonrelapse mortality (NRM). The aim of the current analysis was to compare transplantation outcomes in male patients given female unrelated cord blood (UCB) versus other gender combinations. Patients and methods: Data from 552 consecutive patients with acute myeloid leukemia (AML) given a single UCB transplantation between 2000 and 2014 were included. Results: In comparison with other gender combination, male patients given female UCB (n = 131) had a trend for a higher incidence of grades II-IV acute GVHD (33 versus 25 %, P = 0.08), a trend for a higher incidence of NRM (41 versus 33 %, P = 0.06), and a lower leukemia-free (LFS, 30 versus 41 %, P = 0.01) and overall survival (OS, 33 versus 45 %, P = 0.008). In multivariate analyses, taking into consideration all patients for which data on HLA-matching and cell dose transplanted were fully available (n = 363), male patients transplanted with a female UCB had a trend for a higher incidence of grade III-IV acute GVHD (hazard ratio (HR) = 2.0, P = 0.06), a trend for a higher NRM (HR = 1.5, P = 0.06), and a worse LFS (HR = 1.4, P = 0.04) and OS (HR = 1.3, P = 0.06). Conclusions: Our data suggest that male patients transplanted with female UCB might have higher risk of acute GVHD and of NRM leading to worse LFS and OS. These results should be confirmed in other large cohorts of patients before used for determining the choice of an UCB unit.

Original languageEnglish
Article number107
JournalJournal of Hematology and Oncology
Volume8
Issue number1
DOIs
Publication statusPublished - 6 Oct 2015

Keywords

  • AML
  • Female
  • GVHD
  • Male
  • Transplantation
  • Unrelated cord blood

Fingerprint

Dive into the research topics of 'Unrelated cord blood Transplant. for adult patients with acutemyeloid leukemia: Higher incidence of acute graft-versus-host Dis. and lower survival inmale patients transplanted with female unrelated cord blood - A report from Eurocord, the Acute Leukemia Working Party, and the Cord Blood Comm. of the Cell. Ther. and Immunobiol. Working Party of the Europ. Group for Blood and Marrow Transplant.'. Together they form a unique fingerprint.

Cite this