We report the case of a 48-year-old male patient with a 3-year history of progressive behavioral, memory, and language disorder. Successive examinations revealed a rapid and relatively specific deterioration of left frontotemporal neuropsychological functioning. Neuroradiological imaging (CT and MRI) showed predominant left frontotemporal involvement. We interpret this case as Pick’s disease and describe the neuropsychological involutive characteristics. Other dementias with asymmetric clinicopathological presentation are discussed. © 1988, Taylor & Francis Group, LLC. All rights reserved.