Ultrastructural features of highly active antiretroviral therapy-associated partial lipodystrophy

Josep Lloreta, Pere Domingo, Ramón M. Pujol, Juan A. Arroyo, Núria Baixeras, Xavier Matias-Guiu, Montserrat Gilaberte, Maria A. Sambeat, Sergi Serrano

Research output: Contribution to journalArticleResearchpeer-review

41 Citations (Scopus)

Abstract

Chronic treatment with highly active antiretroviral therapy (HAART) results in a novel variety of partial lipodystrophy, combining lipoatrophic and hypertrophic areas. We have previously reported the histopathological features of this disease and have also shown that adipocyte apoptosis is involved in its origin. With the aim of further elucidating the mechanisms underlying this peculiar disorder, we performed an ultrastructural study of the adipocytes of ten HIV-1-infected patients treated with HAART for 20-42 months. In all ten cases, two main sets of ultrastructural changes were identified. Some adipocytes showed disruption of cell membranes, fragmented cytoplasmic rims, irregular cell outlines, and eventually fat droplets laying free in the connective tissue, with a histiocytic reaction around them. In addition, many adipocytes showed variable compartmentalization of fat droplets with decrease in cell size and abundant, mitochondria-rich cytoplasm. Often, a dual "white and brown" fat appearance was observed with a large unilocular vacuole surrounded by a rim of multilocular cytoplasm containing smaller isometric fat droplets and numerous mitochondria. These findings suggest that HAART-associated partial lipodystrophy is probably the result of a remodeling process of fat cells involving variable combinations of apoptosis, defective lipogenesis, and increased metabolic activity in different adipose areas of the body.
Original languageEnglish
Pages (from-to)599-604
JournalVirchows Archiv
Volume441
DOIs
Publication statusPublished - 19 Dec 2002

Keywords

  • AIDS
  • Apoptosis
  • Electron microscopy
  • Highly active antiretroviral therapy
  • Lipodystrophy

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