Ultrasound-guided compared to conventional treatment in gestational diabetes leads to improved birthweight but more insulin treatment: Systematic review and meta-analysis

Montserrat Balsells, Apolonia García-Patterson, Ignasi Gich, Rosa Corcoy

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14 Citations (Scopus)

Abstract

Objective To perform a systematic review and meta-analysis of randomized controlled trials assessing ultrasound-guided versus conventional management in women with a broad severity-spectrum of gestational diabetes mellitus. Design Systematic review and meta-analysis of trials published until August 2012. Setting PubMed and Web of Science databases. Study selection and methods Eighteen studies were reviewed in full text. Eligibility criteria were (i) randomized controlled trials comparing metabolic management in women with gestational diabetes mellitus and ultrasound-based vs. the conventional management to assess fetal growth, (ii) representative of the whole spectrum of hyperglycemia and fetal growth, (iii) data on perinatal outcomes. Review Manager 5.0 was used to summarize the results. Results Two studies fulfilled inclusion criteria. The ultrasound-guided group had a lower rate of large-for-gestational age newborns (relative risk 0.58, 95% confidence interval 0.34-0.99), macrosomia (relative risk 0.32, 95% confidence interval 0.11-0.95) and abnormal birthweight (small/large-for-gestational age, relative risk 0.64, 95% confidence interval 0.45-0.93) and a higher rate of insulin treatment (relative risk 1.58, 95% confidence interval 1.14-2.20). The number of women with gestational diabetes with a need to treat to prevent an additional newborn with abnormal birthweight was 10. Conclusions In women with a broad severity-spectrum of gestational diabetes mellitus, ultrasound-guided management improves birthweight distribution, but increases the need for insulin treatment. More research is needed in this area because results are derived from a limited number of patients. © 2013 Nordic Federation of Societies of Obstetrics and Gynecology.
Original languageEnglish
Pages (from-to)144-151
JournalActa Obstetricia et Gynecologica Scandinavica
Volume93
Issue number2
DOIs
Publication statusPublished - 1 Feb 2014

Keywords

  • Gestational diabetes mellitus
  • insulin therapy
  • meta-analysis
  • randomized control trial
  • systematic review
  • ultrasound

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