Type 2 diabetes and cognitive impairment in an older population with overweight or obesity and metabolic syndrome: baseline cross-sectional analysis of the PREDIMED-plus study

Núria Mallorquí-Bagué, María Lozano-Madrid, Estefanía Toledo, Dolores Corella, Jordi Salas-Salvadó, Aida Cuenca-Royo, Jesús Vioque, Dora Romaguera, J. Alfredo Martínez, Julia Wärnberg, José López-Miranda, Ramón Estruch, Aurora Bueno-Cavanillas, Ángel Alonso-Gómez, Josep A. Tur, Francisco J. Tinahones, Lluís Serra-Majem, Vicente Martín, José Lapetra, Clotilde VázquezXavier Pintó, Josep Vidal, Lidia Daimiel, José J. Gaforio, Pilar Matía, Emilio Ros, Roser Granero, Pilar Buil-Cosiales, Rocío Barragán, Mònica Bulló, Olga Castañer, Manoli García-de-la-Hera, Aina M. Yáñez, Itziar Abete, Antonio García-Ríos, Miguel Ruiz-Canela, Andrés Díaz-López, Susana Jiménez-Murcia, Miguel A. Martínez-González, Rafael De la Torre, Fernando Fernández-Aranda

Research output: Contribution to journalArticleResearch

14 Citations (Scopus)

Abstract

© 2018, The Author(s). This study cross-sectionally examines in the elderly population: (a) the association of type 2 diabetes with executive function (EF); (b) the effect of BMI on both type 2 diabetes and EF; (c) the association between glycaemia control and EF in type 2 diabetes. 6823 older individuals with overweight/obesity and metabolic syndrome participating in the PREDIMED-PLUS study, were assessed with a battery of cognitive tests and a medical interview. ANOVA showed a significantly worse performance on EF in type 2 diabetes vs. non-diabetic individuals. Two complementary models were displayed: (1) in the whole sample, the presence of type 2 diabetes, depressive symptoms and BMI had a direct negative effect on EF, while apnoea had an indirect negative effect; (2) in the diabetes subsample, higher illness duration was associated with worse performance in EF. Participants with type 2 diabetes and HbA1c<53 mmol/mol displayed better cognitive performance when compared to those with HbA1c≥53 mmol/mol. Our results provide a controlled comprehensive model that integrates relevant neuropsychological and physical variables in type 2 diabetes. The model suggests that, to improve treatment adherence and quality of life once diabetes has been diagnosed, cognitive decline prevention strategies need to be implemented while monitoring depressive symptoms, BMI and glycaemia control.
Original languageEnglish
Article number16128
Pages (from-to)-
JournalScientific Reports
Volume8
DOIs
Publication statusPublished - 1 Dec 2018

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