Type 1 diabetic subjects with diabetic retinopathy show an unfavorable pattern of fat intake

Minerva Granado-Casas, Anna Ramírez-Morros, Mariona Martín, Jordi Real, Núria Alonso, Xavier Valldeperas, Alicia Traveset, Esther Rubinat, Nuria Alcubierre, Marta Hernández, Manel Puig-Domingo, Albert Lecube, Esmeralda Castelblanco, Didac Mauricio

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Abstract

© 2018 by the authors. Licensee MDPI, Basel, Switzerland. Medical nutrition therapy is an important part of the management of type 1 diabetes mellitus (T1DM). Proper adherence to a healthy diet may have a favorable impact on diabetes management and its diabetic complications. Our aim was to assess differences in food and nutrient intake of type 1 diabetic patients with and without diabetic retinopathy (DR). This was a two-center, cross-sectional study in patients with T1DM, with and without DR. Subjects were recruited from the outpatient clinic of the two participating centers. A validated food frequency questionnaire was administered. A total of 103 T1DM patients with DR and 140 T1DM patient without DR were recruited. Subjects with DR showed a lower intake of total fat (p = 0.036) than that of their non-DR counterparts. DR was associated with increasing age (p = 0.004), hypertension (p < 0.001), and diabetes duration (p < 0.001), however there was a negative association with high educational level (p = 0.018). The multivariate-adjusted analysis showed that the intake of complex carbohydrates was positively related to the presence of DR (p = 0.031). In contrast, the intakes of total fat (p = 0.009), monounsaturated fatty acids (MUFAs) (p = 0.012), oleic acid (p = 0.012), and vitamin E (p = 0.006) were associated with the absence of DR. As conclusions, the intake of total MUFAs, oleic acid, and vitamin E is associated with a lower frequency of DR in patients with T1DM. These results suggest a potential protective effect of these lipid components for DR.
Original languageEnglish
Article number1184
JournalNutrients
Volume10
Issue number9
DOIs
Publication statusPublished - 1 Sep 2018

Keywords

  • Carbohydrates
  • Diabetic retinopathy
  • Dietary pattern
  • Fatty acids
  • Oleic acid
  • Type 1 diabetes

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    Granado-Casas, M., Ramírez-Morros, A., Martín, M., Real, J., Alonso, N., Valldeperas, X., Traveset, A., Rubinat, E., Alcubierre, N., Hernández, M., Puig-Domingo, M., Lecube, A., Castelblanco, E., & Mauricio, D. (2018). Type 1 diabetic subjects with diabetic retinopathy show an unfavorable pattern of fat intake. Nutrients, 10(9), [1184]. https://doi.org/10.3390/nu10091184