Type 1 diabetes and the HLA-D locus

J. A. Sachs; A. G. Cudworth; D. Jaraquemada; A. N. Gorsuch; H. Festenstein

doi:10.1007/BF01228300

Type 1 diabetes and the HLA-D locus

J. A. Sachs^*, A. G. Cudworth, D. Jaraquemada, A. N. Gorsuch, H. Festenstein

^*Corresponding author for this work

Department of Cellular Biology, Physiology and Immunology

Research output: Contribution to journal › Article › Research › peer-review

57 Citations (Scopus)

Abstract

HLA-D specificities have been investigated in 58 classical Type 1 diabetics and 43 healthy subjects. Both groups were selected according to the HLA-B locus antigens which are known to have a significant positive or negative association with the disease. The results indicate that (1) the primary association of the disease is with HLA-DW3, (2) the increased frequency of DW4 in diabetics with rare exception is co-existent with the presence of DW3, (3) the low frequency of DW2 is secondary to the increase in DW3 and/or DW4, and is not consistent with a primary 'protective' role. It is suggested that these data support the hypothesis of interaction between HLA-linked genes operating by separate mechanisms to confer the susceptibility to young onset Type 1 diabetes (Type 1 A).

Original language	English
Pages (from-to)	41-43
Number of pages	3
Journal	Diabetologia
Volume	18
Issue number	1
DOIs	https://doi.org/10.1007/BF01228300
Publication status	Published - Jan 1980

Keywords

Genetic susceptibility in diabetes
HLA-DW typing
the HLA system in diabetes
Type 1 diabetes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/BF01228300

Cite this

@article{0b8d6fecc8e241409176c7293fce33f8,

title = "Type 1 diabetes and the HLA-D locus",

abstract = "HLA-D specificities have been investigated in 58 classical Type 1 diabetics and 43 healthy subjects. Both groups were selected according to the HLA-B locus antigens which are known to have a significant positive or negative association with the disease. The results indicate that (1) the primary association of the disease is with HLA-DW3, (2) the increased frequency of DW4 in diabetics with rare exception is co-existent with the presence of DW3, (3) the low frequency of DW2 is secondary to the increase in DW3 and/or DW4, and is not consistent with a primary 'protective' role. It is suggested that these data support the hypothesis of interaction between HLA-linked genes operating by separate mechanisms to confer the susceptibility to young onset Type 1 diabetes (Type 1 A).",

keywords = "Genetic susceptibility in diabetes, HLA-DW typing, the HLA system in diabetes, Type 1 diabetes",

author = "Sachs, {J. A.} and Cudworth, {A. G.} and D. Jaraquemada and Gorsuch, {A. N.} and H. Festenstein",

year = "1980",

month = jan,

doi = "10.1007/BF01228300",

language = "English",

volume = "18",

pages = "41--43",

number = "1",

}

TY - JOUR

T1 - Type 1 diabetes and the HLA-D locus

AU - Sachs, J. A.

AU - Cudworth, A. G.

AU - Jaraquemada, D.

AU - Gorsuch, A. N.

AU - Festenstein, H.

PY - 1980/1

Y1 - 1980/1

N2 - HLA-D specificities have been investigated in 58 classical Type 1 diabetics and 43 healthy subjects. Both groups were selected according to the HLA-B locus antigens which are known to have a significant positive or negative association with the disease. The results indicate that (1) the primary association of the disease is with HLA-DW3, (2) the increased frequency of DW4 in diabetics with rare exception is co-existent with the presence of DW3, (3) the low frequency of DW2 is secondary to the increase in DW3 and/or DW4, and is not consistent with a primary 'protective' role. It is suggested that these data support the hypothesis of interaction between HLA-linked genes operating by separate mechanisms to confer the susceptibility to young onset Type 1 diabetes (Type 1 A).

AB - HLA-D specificities have been investigated in 58 classical Type 1 diabetics and 43 healthy subjects. Both groups were selected according to the HLA-B locus antigens which are known to have a significant positive or negative association with the disease. The results indicate that (1) the primary association of the disease is with HLA-DW3, (2) the increased frequency of DW4 in diabetics with rare exception is co-existent with the presence of DW3, (3) the low frequency of DW2 is secondary to the increase in DW3 and/or DW4, and is not consistent with a primary 'protective' role. It is suggested that these data support the hypothesis of interaction between HLA-linked genes operating by separate mechanisms to confer the susceptibility to young onset Type 1 diabetes (Type 1 A).

KW - Genetic susceptibility in diabetes

KW - HLA-DW typing

KW - the HLA system in diabetes

KW - Type 1 diabetes

UR - http://www.scopus.com/inward/record.url?scp=0018841886&partnerID=8YFLogxK

U2 - 10.1007/BF01228300

DO - 10.1007/BF01228300

M3 - Article

C2 - 7364163

AN - SCOPUS:0018841886

SN - 0012-186X

VL - 18

SP - 41

EP - 43

JO - Diabetologia

JF - Diabetologia

IS - 1

ER -

Type 1 diabetes and the HLA-D locus

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this