Type 1 diabetes and the HLA-D locus

J. A. Sachs*, A. G. Cudworth, D. Jaraquemada, A. N. Gorsuch, H. Festenstein

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

54 Citations (Scopus)

Abstract

HLA-D specificities have been investigated in 58 classical Type 1 diabetics and 43 healthy subjects. Both groups were selected according to the HLA-B locus antigens which are known to have a significant positive or negative association with the disease. The results indicate that (1) the primary association of the disease is with HLA-DW3, (2) the increased frequency of DW4 in diabetics with rare exception is co-existent with the presence of DW3, (3) the low frequency of DW2 is secondary to the increase in DW3 and/or DW4, and is not consistent with a primary 'protective' role. It is suggested that these data support the hypothesis of interaction between HLA-linked genes operating by separate mechanisms to confer the susceptibility to young onset Type 1 diabetes (Type 1 A).

Original languageEnglish
Pages (from-to)41-43
Number of pages3
JournalDiabetologia
Volume18
Issue number1
DOIs
Publication statusPublished - Jan 1980

Keywords

  • Genetic susceptibility in diabetes
  • HLA-DW typing
  • the HLA system in diabetes
  • Type 1 diabetes

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