TY - JOUR
T1 - Tuberomammillary nucleus lesion facilitates two-way active avoidance retention in rats
AU - Segura-Torres, Pilar
AU - Wagner, Uwe
AU - Massanes-Rotger, Ester
AU - Aldavert-Vera, Laura
AU - Marti-Nicolovius, Margarita
AU - Morgado-Bernal, Ignacio
PY - 1996/1/1
Y1 - 1996/1/1
N2 - To evaluate whether the tuberomammillary nucleus might be involved in the acquisition and/or retention of a two-way active avoidance conditioning, rats were given a unilateral lesion of the tuberomammillary nucleus (E2 region) 24 h prior to the first conditioning session. Four learning sessions were performed: one acquisition and 3 retention sessions (short-term, 24 h; and long-term, 8 and 18 days). Results showed that the lesion facilitated the long-term retention of conditioning, but no effects were observed on acquisition and short-term retention. Since rewarding intracranial electrical stimulation seems to be a consistent way to facilitate learning and memory processes, and tuberomammillary lesion has been shown to improve intracranial self-stimulation behavior (ICSS), we suggest that lesions in the present experiment could have facilitated two-way active avoidance retention by enhancing the function of brain reward mechanisms.
AB - To evaluate whether the tuberomammillary nucleus might be involved in the acquisition and/or retention of a two-way active avoidance conditioning, rats were given a unilateral lesion of the tuberomammillary nucleus (E2 region) 24 h prior to the first conditioning session. Four learning sessions were performed: one acquisition and 3 retention sessions (short-term, 24 h; and long-term, 8 and 18 days). Results showed that the lesion facilitated the long-term retention of conditioning, but no effects were observed on acquisition and short-term retention. Since rewarding intracranial electrical stimulation seems to be a consistent way to facilitate learning and memory processes, and tuberomammillary lesion has been shown to improve intracranial self-stimulation behavior (ICSS), we suggest that lesions in the present experiment could have facilitated two-way active avoidance retention by enhancing the function of brain reward mechanisms.
KW - learning
KW - lesion
KW - memory
KW - tuberomammillary nucleus
KW - two-way active avoidance
U2 - https://doi.org/10.1016/S0166-4328(97)81114-X
DO - https://doi.org/10.1016/S0166-4328(97)81114-X
M3 - Article
VL - 82
SP - 113
EP - 117
JO - Behavioural Brain Research
JF - Behavioural Brain Research
SN - 0166-4328
ER -