Tuberomammillary nucleus lesion facilitates two-way active avoidance retention in rats

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To evaluate whether the tuberomammillary nucleus might be involved in the acquisition and/or retention of a two-way active avoidance conditioning, rats were given a unilateral lesion of the tuberomammillary nucleus (E2 region) 24 h prior to the first conditioning session. Four learning sessions were performed: one acquisition and 3 retention sessions (short-term, 24 h; and long-term, 8 and 18 days). Results showed that the lesion facilitated the long-term retention of conditioning, but no effects were observed on acquisition and short-term retention. Since rewarding intracranial electrical stimulation seems to be a consistent way to facilitate learning and memory processes, and tuberomammillary lesion has been shown to improve intracranial self-stimulation behavior (ICSS), we suggest that lesions in the present experiment could have facilitated two-way active avoidance retention by enhancing the function of brain reward mechanisms.
Original languageEnglish
Pages (from-to)113-117
JournalBehavioural Brain Research
Publication statusPublished - 1 Jan 1996


  • learning
  • lesion
  • memory
  • tuberomammillary nucleus
  • two-way active avoidance


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