Infección y enfermedad tuberculosa en relación con concentraciones plasmáticas de vitamina D

Translated title of the contribution: Tuberculosis: Plasma levels of vitamin D and its relation with infection and disease

Erika Esteve Palau, Francesca Sánchez Martínez*, Hernando Knobel Freud, José Luís López Colomés, Adolfo Diez Pérez

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Abstract

Background and objective Vitamin D (vitD) is involved in the phosphor-calcium metabolism and bone pathology, but also in inflammatory and infectious processes such as tuberculosis. The present study evaluates the clinical and epidemiological aspects of active tuberculosis cases and latently infected contacts in whom plasma concentrations of vitD were obtained to determine whether the deficiency of vitD is a risk factor to develop active tuberculosis, especially the more severe forms. Method Observational, retrospective study that included 86 tuberculosis patients and 80 contacts with latent infection in a 2-year period. Results When comparing active tuberculosis cases with latent infection contacts, deficiency of vitD (vitD levels <10 ng/mL, odds ratio [OR]: 2.02, 95% confidence interval [CI]: 1.04 to 3.93), male sex (OR: 1.9, 95% CI: 0.96 to 3.71) and non-white race (OR: 0.7, 95% CI: 0.34 to 1.42) were factors independently associated with the diagnosis of tuberculosis. Conclusion Despite the limited number of subjects studied, there was a association between severe deficit of vitD and the presentation of tuberculosis.

Translated title of the contributionTuberculosis: Plasma levels of vitamin D and its relation with infection and disease
Original languageSpanish
Pages (from-to)111-114
Number of pages4
JournalMedicina Clinica
Volume144
Issue number3
DOIs
Publication statusPublished - 2 Feb 2015

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