Tuberculosis in solid-organ transplant recipients: Consensus statement of the Group for the Study of Infection in transplant recipients (GESITRA) of the Spanish society of infectious diseases and clinical microbiology

Josemaria Aguado*, Julian Torre-Cisneros, Jesus Fortun, Natividad Benito, Yolanda Meije, Antonio Doblas, Patricia Munoz

*Corresponding author for this work

Research output: Contribution to journalReview articleResearchpeer-review

170 Citations (Scopus)

Abstract

Tuberculosis is a particularly important condition in solid-organ transplant recipients because of the delay in treatment caused by the difficulties involved in its diagnosis and because of the pharmacological toxicity associated with this treatment. Both treatment delay and toxicity are responsible for the many clinical complications of and high mortality associated with tuberculosis in this population. The Consensus Statement from the Spanish Group for the Study of Infectious Diseases in Transplant Recipients defines the indications for treatment of latent tuberculosis infection in solid-organ transplant recipients, especially in patients with a high risk of pharmacological toxicity, as is the case with liver recipients. We established a series of recommendations regarding the types of drugs and the duration of treatment of tuberculosis in solid-organ recipients, giving special attention to pharmacological interactions between rifampin and immunosuppressive drugs (cyclosporine, tacrolimus, rapamycin, and corticosteroids).

Original languageAmerican English
Pages (from-to)1276-1284
Number of pages9
JournalClinical Infectious Diseases
Volume48
Issue number9
DOIs
Publication statusPublished - 1 May 2009

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