Tuberculin immunotherapy: its history and lessons to be learned

Cristina Vilaplana, Pere Joan Cardona*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)


The use of tuberculin for the therapy of tuberculosis was attempted more than 100 years ago and abandoned because of its adverse reactions. In this historical review we point out that some of the intensive efforts to avoid the reactions were based on the best scientific rationale available at that time. Balancing the dosage and intervals of tuberculin delivery with clinical and laboratory monitoring of patients achieved a limited success, with implications, toward current research in the field. The role of economical and social aspects at that time is also a lesson to be learned toward current approaches to tuberculosis control.

Original languageEnglish
Pages (from-to)99-105
Number of pages7
JournalMicrobes and Infection
Issue number2
Publication statusPublished - Feb 2010


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