Trombofilia congénita y aborto recurrente: estrategias diagnósticas y recomendaciones terapéuticas

Translated title of the contribution: Recurrent miscarriage and inherited thrombophilia: diagnostic work-out and therapeutic management

Jaume Alijotas-Reig, Juan Carlos Ferrer-Raventós

Research output: Contribution to journalReview articleResearchpeer-review

11 Citations (Scopus)

Abstract

Pregnancy is a well recognized thrombophilic risk factor. Recurrent abortion (RA) affect up to 3% of fertile couples. A 50% of these cases are considered as idiopathic. Some of them may have one or more than one thrombophilic alterations. RA may be related to placental flow abnormalities. Up to 1% to 5% of all pregnancies may be complicated with placental flow abnormalities. Antiphospholipid syndrome, PS, PC, ATIII deficiencies, factor V, prothrombin, methylentetrahydrofolate reductase, plasminogen activator inhibitor type 1, fibrinogen and factor XIII polymorphisms, have been strongly related to bad obstetric outcomes, specially RA. The presence of more than one thrombophilic factor may be present in pregnant women, rising the risk of suffering RA. All pregnant patients and those who planed a future conception having a history of thrombotic events, independently of their previous obstetric outcomes, need to be studied for thrombophilia. All patients with RA specially if it appeared in the late-pregnancy, have also to be studied. Early antiaggregant and/or anticoagulant therapy, reduces the maternal-fetal risk.

Translated title of the contributionRecurrent miscarriage and inherited thrombophilia: diagnostic work-out and therapeutic management
Original languageSpanish
Pages (from-to)626-31
Number of pages6
JournalMedicina clinica
Volume125
Issue number16
DOIs
Publication statusPublished - 5 Nov 2005

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