We describe two cases of transitional cell carcinoma of the bladder associated with trisomy 7. In one of them, trisomy 7 was the only chromosomes abnormality observed. In the second case, trisomy 7 was found in 25 (80.6%) of the metaphases; in two of them this was the only anomaly, while in three metaphases trisomy 8 was also present, and in other two trisomy 10 was also observed. Our results suggest that trisomy 7 could be a primary change in TCC, and a review of the literature indicates that when it is present as the sole karyotypic abnormality is may be associated with a non-invasive behavior of the tumor. © 1990.
|Journal||Cancer Genetics and Cytogenetics|
|Publication status||Published - 1 Jan 1990|
Berrozpe, G., Miró, R., Rosa Cabalin, M., Salvador, J., & Egozcue, J. (1990). Trisomy 7 may be a primary change in non-invasive transitional cell carcinoma of the bladder. Cancer Genetics and Cytogenetics, 50, 9-14. https://doi.org/10.1016/0165-4608(90)90232-Y