Tricyclic antidepressants activate the pituitary-adrenal axis in the rat. Tolerance to repeated drug administration

Antonio Armario, Cristina García-Marquez

    Research output: Contribution to journalArticleResearchpeer-review

    19 Citations (Scopus)

    Abstract

    The effects of acute and chronic administration of tricyclic antidepressants on the pituitary-adrenal axis were studied in adult male rats. Acute administration of desipramine, imipramine and chlorimipramine activated the pituitary-adrenal axis. The effect of imipramine was found to be of short duration with a significant increase at 30 and 60 min after the administration of the drug and a return to baseline levels at 180 min. The effect of imipramine was dose-dependent. Twenty hours after the last drug administration rats chronically injected with chlorimipramine showed normal basal and saline-induced levels of corticosterone. However the response of these rats to an acute dose of chlorimipramine was significantly lower than that of drug-naive rats, indicating tolerance to the drug. The mechanisms involved in the activation of the pituitary-adrenal axis caused by antidepressants and the tolerance to repeated drug administration are still unknown. © 1987.
    Original languageEnglish
    Pages (from-to)239-244
    JournalEuropean Journal of Pharmacology
    Volume140
    DOIs
    Publication statusPublished - 11 Aug 1987

    Keywords

    • Chlorimipramine
    • Desipramine
    • Imipramine
    • Pituitary-adrenal axis
    • Tricyclic antidepressants

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