Treatment with interferon-beta does not induce anti-nuclear and anti-neuronal serum autoantibodies in multiple sclerosis patients

M. Comabella; K. Rentzsch; J. Río; M. F. Bustamante; K. Borowski; W. Stoecker; X. Montalban

doi:10.1016/j.jneuroim.2012.10.016

Treatment with interferon-beta does not induce anti-nuclear and anti-neuronal serum autoantibodies in multiple sclerosis patients

M. Comabella^*, K. Rentzsch, J. Río, M. F. Bustamante, K. Borowski, W. Stoecker, X. Montalban

^*Corresponding author for this work

Department of Medicine

Research output: Contribution to journal › Article › Research › peer-review

2 Citations (Scopus)

Abstract

Type I interferons (IFNs) are known to enhance humoral immunity. Here, we investigated the prevalence and titer of anti-nuclear and anti-neuronal IgG autoantibodies in 71 relapsing-remitting MS patients classified based on their clinical response to IFNβ in paired sera obtained at baseline and after 12. months of treatment. All samples were negative for antibodies against cytoplasmic rods/rings, synaptic proteins and paraneoplastic antibodies. Regarding anti-nuclear, anti-filament and anti-myelin antibodies, pre- and post-treatment prevalence and titers did not differ significantly between IFNβ responders and non-responders. Thus, pattern of anti-nuclear and anti-neuronal autoantibodies does not predict the response to IFNβ in MS patients.

Original language	English
Pages (from-to)	102-104
Number of pages	3
Journal	Journal of Neuroimmunology
Volume	255
Issue number	1-2
Early online date	26 Nov 2012
DOIs	https://doi.org/10.1016/j.jneuroim.2012.10.016
Publication status	Published - 15 Feb 2013

Keywords

Humoral immunity, autoantibodies
Interferon-beta
Multiple sclerosis
Response to treatment

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10.1016/j.jneuroim.2012.10.016

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title = "Treatment with interferon-beta does not induce anti-nuclear and anti-neuronal serum autoantibodies in multiple sclerosis patients",

abstract = "Type I interferons (IFNs) are known to enhance humoral immunity. Here, we investigated the prevalence and titer of anti-nuclear and anti-neuronal IgG autoantibodies in 71 relapsing-remitting MS patients classified based on their clinical response to IFNβ in paired sera obtained at baseline and after 12. months of treatment. All samples were negative for antibodies against cytoplasmic rods/rings, synaptic proteins and paraneoplastic antibodies. Regarding anti-nuclear, anti-filament and anti-myelin antibodies, pre- and post-treatment prevalence and titers did not differ significantly between IFNβ responders and non-responders. Thus, pattern of anti-nuclear and anti-neuronal autoantibodies does not predict the response to IFNβ in MS patients.",

keywords = "Humoral immunity, autoantibodies, Interferon-beta, Multiple sclerosis, Response to treatment",

author = "M. Comabella and K. Rentzsch and J. R{\'i}o and Bustamante, \{M. F.\} and K. Borowski and W. Stoecker and X. Montalban",

note = "Funding Information: The authors thank the “Red Espa{\~n}ola de Esclerosis M{\'u}ltiple (REEM)” sponsored by the “Fondo de Investigaci{\'o}n Sanitaria” (FIS), Ministry of Science and Innovation , Spain, and the “Ajuts per donar Suport als Grups de Recerca de Catalunya,” sponsored by the “Ag{\`e}ncia de Gesti{\'o} d'Ajuts Universitaris i de Recerca” (AGAUR), Generalitat de Catalunya , Spain. ",

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doi = "10.1016/j.jneuroim.2012.10.016",

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T1 - Treatment with interferon-beta does not induce anti-nuclear and anti-neuronal serum autoantibodies in multiple sclerosis patients

AU - Comabella, M.

AU - Rentzsch, K.

AU - Río, J.

AU - Bustamante, M. F.

AU - Borowski, K.

AU - Stoecker, W.

AU - Montalban, X.

N1 - Funding Information: The authors thank the “Red Española de Esclerosis Múltiple (REEM)” sponsored by the “Fondo de Investigación Sanitaria” (FIS), Ministry of Science and Innovation , Spain, and the “Ajuts per donar Suport als Grups de Recerca de Catalunya,” sponsored by the “Agència de Gestió d'Ajuts Universitaris i de Recerca” (AGAUR), Generalitat de Catalunya , Spain.

PY - 2013/2/15

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N2 - Type I interferons (IFNs) are known to enhance humoral immunity. Here, we investigated the prevalence and titer of anti-nuclear and anti-neuronal IgG autoantibodies in 71 relapsing-remitting MS patients classified based on their clinical response to IFNβ in paired sera obtained at baseline and after 12. months of treatment. All samples were negative for antibodies against cytoplasmic rods/rings, synaptic proteins and paraneoplastic antibodies. Regarding anti-nuclear, anti-filament and anti-myelin antibodies, pre- and post-treatment prevalence and titers did not differ significantly between IFNβ responders and non-responders. Thus, pattern of anti-nuclear and anti-neuronal autoantibodies does not predict the response to IFNβ in MS patients.

AB - Type I interferons (IFNs) are known to enhance humoral immunity. Here, we investigated the prevalence and titer of anti-nuclear and anti-neuronal IgG autoantibodies in 71 relapsing-remitting MS patients classified based on their clinical response to IFNβ in paired sera obtained at baseline and after 12. months of treatment. All samples were negative for antibodies against cytoplasmic rods/rings, synaptic proteins and paraneoplastic antibodies. Regarding anti-nuclear, anti-filament and anti-myelin antibodies, pre- and post-treatment prevalence and titers did not differ significantly between IFNβ responders and non-responders. Thus, pattern of anti-nuclear and anti-neuronal autoantibodies does not predict the response to IFNβ in MS patients.

KW - Humoral immunity, autoantibodies

KW - Interferon-beta

KW - Multiple sclerosis

KW - Response to treatment

UR - https://www.scopus.com/pages/publications/84872651094

U2 - 10.1016/j.jneuroim.2012.10.016

DO - 10.1016/j.jneuroim.2012.10.016

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AN - SCOPUS:84872651094

SN - 0165-5728

VL - 255

SP - 102

EP - 104

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

IS - 1-2

ER -

Treatment with interferon-beta does not induce anti-nuclear and anti-neuronal serum autoantibodies in multiple sclerosis patients

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