Treatment of renal colic with dipyrone. A double-blind comparison trial with hyoscine alone or combined with dipyrone

J. Lloret, J. Munoz, J. Monmany, X. Puig, M. Bonastre, J. Brau, J. Sola, P. Domingo, F. Jane

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    Abstract

    In this double-blind, randomized trial, 96 patients with renal colic were treated intravenously with dipyrone sodium 2.5 gm (25 patients), dipyrone sodium 2.5 mg plus hyoscine N-butilbromide 20 mg (25 patients), dipyrone sodium 1.0 gm (23 patients), or with hyoscine N-butilbromide 20 mg (23 patients). Patients evaluated pain intensity in baseline conditions and 10, 20, and 30 minutes after injection. In cases of insufficient response to treatment (pain relief <50%), patients received a narcotic analgesic. Therapeutic regimens containing high-dose (2.5 gm) dipyrone produced a more significant reduction in pain score compared with those containing low-dose (1.0 gm) dipyrone (P<0.05) or hyoscine alone (P<0.001). Fewer patients treated with high-dose dipyrone than with hyoscine alone needed a narcotic analgesic (P<0.001). There were no significant differences between those regimens containing high-dose dipyrone whether or not hyoscine was added. Pain at injection site was significantly more frequent in those patients treated with high-dose dipyrone (P<0.001), whereas dryness of the mouth was significantly more frequent in those treated with hyoscine (P<0.025). Evaluation of pain intensity by the patients and clinicians showed a good correlation (P<0.001).
    Original languageEnglish
    Pages (from-to)1119-1128
    JournalCurrent Therapeutic Research - Clinical and Experimental
    Volume42
    Issue number6
    Publication statusPublished - 1 Jan 1987

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