Treatment of endometrial hyperplasia without atypia in peri- and postmenopausal women with a levonorgestrel intrauterine device

Sergio Haimovich, Miguel A. Checa, Gemma Mancebo, Pere Fusté, Ramón Carreras

Research output: Contribution to journalArticleResearchpeer-review

28 Citations (Scopus)

Abstract

OBJECTIVE: To assess the effectiveness of the Mirena levonorgestrel- releasing intrauterine system (LNG-IUS) in peri- and postmenopausal women with endometrial hyperplasia without atypia. DESIGN: All consecutive women with histologically documented endometrial hyperplasia without atypia recruited during a 1-year period participated in an open, prospective, single-center study. They were followed for at least 2 years after levonorgestrel-releasing intrauterine system insertion. The pattern of uterine bleeding was evaluated on a 4-point qualitative scale (1 = amenorrhea, 2 = scarce, 3 = normal, 4 = abundant). RESULTS: The study population consisted of 15 women with a mean (SD) age of 49 (2.7) years. Compared with baseline, bleeding decreased quantitatively from a mean score of 3 at baseline (normal bleeding) to 2 (scarce) at 3and 6 months, and 1 (amenorrhea) at 24 months. Endometrial biopsies performed at 12 months revealed atrophicendometrium in 14 women (93.3%) and secretory endometrium in 1 (6.7%) (P < 0.001). At 24 months, endometrial atrophy was documented in 100% of women. CONCLUSIONS: The levonorgestrel-releasing intrauterine system seems to be an effective and safe alternative in the treatment of peri- and postmenopausal women with (simple) endometrial hyperplasia without atypia. © 2008 by The North American Menopause Society.
Original languageEnglish
Pages (from-to)1002-1004
JournalMenopause
Volume15
Issue number5
DOIs
Publication statusPublished - 1 Sep 2008

Keywords

  • Abnormal uterine bleeding
  • Endometrial hyperplasia
  • Levonorgestrel-releasing intrauterine system
  • Nonatypical

Fingerprint Dive into the research topics of 'Treatment of endometrial hyperplasia without atypia in peri- and postmenopausal women with a levonorgestrel intrauterine device'. Together they form a unique fingerprint.

Cite this