Transplanted oligodendrocytes and motoneuron progenitors generated from human embryonic stem cells promote locomotor recovery after spinal cord transection

Slaven Erceg, Mohammad Ronaghi, Marc Oria, Mireia García Roselló, Maria Amparo Pérez Aragó, Maria Gomez Lopez, Ivana Radojevic, Victoria Moreno-Manzano, Francisco Javier Rodríguez-Jiménez, Shom Shanker Bhattacharya, Juan Cordoba, Miodrag Stojkovic

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112 Citations (Scopus)

Abstract

Human embryonic stem cells (hESC) hold great promise for the treatment of patients with many neurodegenerative diseases particularly those arising from cell loss or neural dysfunction including spinal cord injury. This study evaluates the therapeutic effects of transplanted hESC-derived oligodendrocyte progenitors (OPC) and/or motoneuron progenitors (MP) on axonal remyelination and functional recovery of adult rats after complete spinal cord transection. OPC and/or MP were grafted into the site of injury in the acute phase. Based on Basso-Beattie-Bresnahan scores recovery of locomotor function was significantly enhanced in rats treated with OPC and/or MP when compared with control animals. When transplanted into the spinal cord immediately after complete transection, OPC and MP survived, migrated, and differentiated into mature oligodendrocytes and neurons showing in vivo electrophysiological activity. Taken together, these results indicate that OPC and MP derived from hESC could be a useful therapeutic strategy to repair injured spinal cord. © AlphaMed Press.
Original languageEnglish
Pages (from-to)1541-1549
JournalStem Cells
Volume28
Issue number9
DOIs
Publication statusPublished - 1 Jan 2010

Keywords

  • Embryonic stem cells
  • Neural differentiation
  • Oligodendrocytes
  • Stem cell transplantation

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    Erceg, S., Ronaghi, M., Oria, M., Roselló, M. G., Aragó, M. A. P., Lopez, M. G., Radojevic, I., Moreno-Manzano, V., Rodríguez-Jiménez, F. J., Bhattacharya, S. S., Cordoba, J., & Stojkovic, M. (2010). Transplanted oligodendrocytes and motoneuron progenitors generated from human embryonic stem cells promote locomotor recovery after spinal cord transection. Stem Cells, 28(9), 1541-1549. https://doi.org/10.1002/stem.489