Transgenic rabbits overexpressing growth hormone develop acromegaly and diabetes mellitus

Cristina Costa, Gemma Solanes, Joana Visa, Fatima Bosch

Research output: Contribution to journalArticleResearchpeer-review

38 Citations (Scopus)


Transgenic rabbits expressing the bovine growth hormone (bGH) gene in liver and kidney were obtained to study the long-term effects of chronic exposure to GH in nonrodent animals. These rabbits presented high levels of bGH and insulin-like growth factor I in serum. In spite of chronic exposure to bGH, transgenic rabbits had similar body weight to controls. However, enlargement of the head and limbs and reduction of visceral fat were observed in these animals. They also showed marked hyperinsulinemia, hyperglycemia, and hypertriglyceridemia, indicating that they developed insulin resistance. Furthermore, serious histopathological alterations, including marked fibrosis, were observed in liver, kidney, and skeletal muscle. These anatomical, metabolic, and histological alterations closely resemble those found in patients with acromegaly. Thus, transgenic rabbits overexpressing GH may be a good model of the human disease.
Original languageEnglish
Pages (from-to)1455-1460
JournalFASEB Journal
Issue number14
Publication statusPublished - 17 Nov 1998


  • Bovine growth hormone
  • Hyperglycemia
  • IGF


Dive into the research topics of 'Transgenic rabbits overexpressing growth hormone develop acromegaly and diabetes mellitus'. Together they form a unique fingerprint.

Cite this