Trafficking of Stretch-Regulated TRPV2 and TRPV4 Channels Inferred Through Interactomics

Pablo Doñate-Macian, Jennifer Enrich-Bengoa, Irene R. Dégano, David G. Quintana, Alex Peralvarez-Marin

Research output: Contribution to journalReview articleResearchpeer-review

3 Citations (Scopus)

Abstract

Transient receptor potential cation channels are emerging as important physiological and therapeutic targets. Within the vanilloid subfamily, transient receptor potential vanilloid 2 (TRPV2) and 4 (TRPV4) are osmo-and mechanosensors becoming critical determinants in cell structure and activity. However, knowledge is scarce regarding how TRPV2 and TRPV4 are trafficked to the plasma membrane or specific organelles to undergo quality controls through processes such as biosynthesis, anterograde/retrograde trafficking, and recycling. This revision lists and reviews a subset of protein–protein interactions from the TRPV2 and TRPV4 interactomes, which is related to trafficking processes such as lipid metabolism, phosphoinositide signaling, vesicle-mediated transport, and synaptic-related exocytosis. Identifying the protein and lipid players involved in trafficking will improve the knowledge on how these stretch-related channels reach specific cellular compartments.

Original languageUndefined/Unknown
Article number791
JournalBiomolecules
Volume9
Issue number12
DOIs
Publication statusPublished - Dec 2019

Keywords

  • Ion channel trafficking
  • Phosphatidylinositol signaling
  • Stretch-related channels
  • TRPV2
  • TRPV4
  • Transient receptor potential channels

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