Toxoplasmosis y embarazo. Estudio multicéntrico realizado en 16.362 gestantes de Barcelona

Translated title of the contribution: Toxoplasmosis and pregnancy. Multicenter study of 16,362 pregnant women in Barcelona

Carme Muñoz Batet*, Cèlia Guardià Llobet, Teresa Juncosa Morros, Lluís Viñas Domenech, Montserrat Sierra Soler, Isabel Sanfeliu Sala, Jordi Bosch Mestres, Eva Dopico Ponte, Josep Lite Lite, Lurdes Matas Andreu, Concha Juste Sánchez, Margarita Barranco Romeu

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

33 Citations (Scopus)

Abstract

BACKGROUND AND OBJECTIVE: The aim of this study was to know: 1) the prevalence of antibodies against toxoplasma in pregnant women, 2) the incidence of primary infection during pregnancy and 3) the prevalence of congenital toxoplasmosis. SUBJECTS AND METHOD: Seroprevalence was prospectively analyzed in 16,362 pregnant women visited in 8 hospitals and 2 day care centers in Barcelona during 1999. Each participant laboratory included their own assays to detect toxoplasma-specific immunoglobulins IgM, IgA, IgG and IgG avidity antibodies. In case of positive specific IgM, a second serum sample was requested, which was processed in parallel with the first one. Three infection stages were defined: acute, possible and past (latent). Congenital infection was determined prenatally by polymerase chain reaction (PCR) in amniotic fluid or postnatally by serology in the newborn. RESULTS: Seroprevalence was 28.6%. The incidence of primary infection during pregnancy was 1.02/1,000 susceptible pregnant women. Nine women out of 12 with an acute toxoplasma infection became seroconverted during their pregnancies and five of them had infants with congenital toxoplasmosis (vertical transmission: 41.6%). All four children born alive had no symptoms during their follow-up. CONCLUSIONS: In this study, the prevalence of toxoplasmosis was low. Acute toxoplasmosis was detected mainly by seroconversion during pregnancy. The frequency of maternal-fetal transmission was near half of cases.

Translated title of the contributionToxoplasmosis and pregnancy. Multicenter study of 16,362 pregnant women in Barcelona
Original languageSpanish
Pages (from-to)12-16
Number of pages5
JournalMedicina Clinica
Volume123
Issue number1
DOIs
Publication statusPublished - 5 Jun 2004

Fingerprint

Dive into the research topics of 'Toxoplasmosis and pregnancy. Multicenter study of 16,362 pregnant women in Barcelona'. Together they form a unique fingerprint.

Cite this