Abstract
Stabilizing the transition state of a reaction is not the only consideration in the design of catalytic antibodies. The energetics of the substrate-catalyst complex preceding the transition state also play a role. The picture shows such a complex for an oxy-Cope rearrangement in the active site of the antibody catalyst AZ-28 in its germline form.
Original language | English |
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Pages (from-to) | 904-909 |
Journal | Angewandte Chemie - International Edition |
Volume | 44 |
Issue number | 6 |
DOIs | |
Publication status | Published - 2 Feb 2005 |
Keywords
- Catalytic antibodies
- Computer chemistry
- Enzyme models
- Oxy-Cope rearrangement