Topographical distribution of motor fascicles in the sciatic-tibial nerve of the rat

Jordi Badia, Arán Pascual-Font, Meritxell Vivó, Esther Udina, Xavier Navarro

Research output: Contribution to journalArticleResearchpeer-review

50 Citations (Scopus)

Abstract

Knowledge of the intraneural topography of peripheral nerves may help to improve nerve repair after injuries and the selectivity of neural interfaces. We studied the fascicular pattern of motor fibers of the rat sciatic-tibial nerve. We carried out an anatomical dissection of the muscular tributaries of the tibial nerve in the leg. Immunohistochemistry against choline acetyltransferase was used to identify motor axons. Retrograde tracing allowed localization of the muscular fascicles at proximal levels of the sciatic trunk. The distribution of motor fibers in transverse section of the tibial nerve is not homogeneous; two clusters were identified, each one containing fibers of functionally related muscles. Retrograde tracing allowed for the identification of motor fascicles, each one well localized along the sciatic nerve. In the rat there is a somatotopic organization of the sciatic nerve, with muscular fascicles maintaining the same relative position along the entire nerve. © 2010 Wiley Periodicals, Inc.
Original languageEnglish
Pages (from-to)192-201
JournalMuscle and Nerve
Volume42
DOIs
Publication statusPublished - 1 Jan 2010

Keywords

  • Axonal tracing
  • Motor fibers
  • Peripheral nerve somatotopy
  • Sciatic nerve
  • Tibial nerve

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