Topical nystatin powder in severe burns: A new treatment for angioinvasive fungal infections refractory to other topical and systemic agents

J. P. Barret*, P. I. Ramzy, J. P. Heggers, C. Villareal, D. N. Herndon, M. H. Desai

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)

Abstract

Angioinvasive fungal infections have a significant morbidity and mortality in the immunocompromised host. Massive burns produce a profound derangement in cellular immunity along with a loss of cutaneous barrier function. Treatment of fungal burn wound infections poses a difficult therapeutic challenge. We present a new method of treatment for angioinvasive fungal infections with nystatin powder at a concentration of 6,000,000 units/g. It proved to be efficacious in four consecutive severely burned patients affected by massive angioinvasive fungal infection. Both superficial and deep tissue infections were eradicated without any other therapeutic interventions or adverse effects on wound healing.

Original languageAmerican English
Pages (from-to)505-508
Number of pages4
JournalBurns
Volume25
Issue number6
DOIs
Publication statusPublished - Sep 1999

Keywords

  • Aspergillus
  • Burns
  • Fusarium
  • Nystatin

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