Tolerability and profile of the side effects of bupropion

Facund Fora, Verónica Gálvez-Ortiz, Narcis Cardoner-Álvarez, Jose M. Crespo-Blanco, Victor Navarro-Odriozola, Gemma Garcia-Parés, Josefina Pérez-Bianco, Manel Sánchez-Pérez, Carlos Roncero

Research output: Contribution to journalReview articleResearchpeer-review


Tolerability and the profile of side effects of bupropion are reviewed based on the current literature with special emphasis on sexual function and body weight. Clear evidence exists that bupropion causes less sexual dysfunction than SSRIs and more limited evidence that bupropion may reverse the secondary sexual effects of the SSRIs. On the other hand, contrasted evidence is found that long-term treatment with SSRI may entail some weight gain, while long term treatment with bupropion may entail mild weight loss. Currently, sufficient scientific evidence does not exist to state that bupropion can reverse SSRI-induced weight gain. The results of the review are compared with the opinion of professionals who manage the drug in the daily clinical practice.
Original languageEnglish
Pages (from-to)20-26
JournalActas Espanolas de Psiquiatria
Issue numberSUPPL. 2
Publication statusPublished - 1 Oct 2011


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