Tocopherol and selenite modulate the transplacental effects induced by sodium arsenite in hamsters

Adriana Sampayo-Reyes; Reyes S. Taméz-Guerra; Mario Bermúdez de León; Javier Vargas-Villarreal; Héctor Gerardo Lozano-Garza; Cristina Rodríguez-Padilla; Constanza Cortés; Ricard Marcos; Alba Hernández

doi:10.1016/j.reprotox.2017.10.003

Tocopherol and selenite modulate the transplacental effects induced by sodium arsenite in hamsters

Adriana Sampayo-Reyes, Reyes S. Taméz-Guerra, Mario Bermúdez de León, Javier Vargas-Villarreal, Héctor Gerardo Lozano-Garza, Cristina Rodríguez-Padilla, Constanza Cortés, Ricard Marcos, Alba Hernández

Research output: Contribution to journal › Article › Research › peer-review

7 Citations (Scopus)

Abstract

© 2017 Elsevier Inc. Human studies suggest that in utero exposure to arsenic results in adverse pregnancy outcomes. The use of dietary supplements, such as sodium selenite (SS) or α-tocopherol succinate (α-TOS), is a reasonable approach to ameliorate such health effects. Sodium arsenite at 100 ppm was administered via drinking water to female hamsters from gestational days 1 or 8 to the time of delivery. Viable fetuses, fetal resorptions and non-viable fetuses were recorded during and after pregnancy and total arsenic and its metabolites were characterized in pregnant animals, placentas and fetuses. Arsenic was found to accumulate in the placenta and fetus, increasing fetal mortality, non-viable fetuses and resorptions. Co-administration of SS and α-TOS significantly reduced the observed teratogenic effects. SS influenced arsenic biotransformation by reducing the MMA/InAs index and increasing the DMA/MMA, whereas α-TOS more likely exerts its protective effect through its potent antioxidant activity.

Original language	English
Pages (from-to)	204-211
Journal	Reproductive Toxicology
Volume	74
DOIs	https://doi.org/10.1016/j.reprotox.2017.10.003
Publication status	Published - 1 Dec 2017

Keywords

Arsenic
Hamster
Selenium
Teratogenesis
Vitamin E

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.reprotox.2017.10.003

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@article{26d9c4369c454989866aea564df7dc18,

title = "Tocopherol and selenite modulate the transplacental effects induced by sodium arsenite in hamsters",

abstract = "{\textcopyright} 2017 Elsevier Inc. Human studies suggest that in utero exposure to arsenic results in adverse pregnancy outcomes. The use of dietary supplements, such as sodium selenite (SS) or α-tocopherol succinate (α-TOS), is a reasonable approach to ameliorate such health effects. Sodium arsenite at 100 ppm was administered via drinking water to female hamsters from gestational days 1 or 8 to the time of delivery. Viable fetuses, fetal resorptions and non-viable fetuses were recorded during and after pregnancy and total arsenic and its metabolites were characterized in pregnant animals, placentas and fetuses. Arsenic was found to accumulate in the placenta and fetus, increasing fetal mortality, non-viable fetuses and resorptions. Co-administration of SS and α-TOS significantly reduced the observed teratogenic effects. SS influenced arsenic biotransformation by reducing the MMA/InAs index and increasing the DMA/MMA, whereas α-TOS more likely exerts its protective effect through its potent antioxidant activity.",

keywords = "Arsenic, Hamster, Selenium, Teratogenesis, Vitamin E",

author = "Adriana Sampayo-Reyes and Tam{\'e}z-Guerra, {Reyes S.} and {Berm{\'u}dez de Le{\'o}n}, Mario and Javier Vargas-Villarreal and Lozano-Garza, {H{\'e}ctor Gerardo} and Cristina Rodr{\'i}guez-Padilla and Constanza Cort{\'e}s and Ricard Marcos and Alba Hern{\'a}ndez",

year = "2017",

month = dec,

day = "1",

doi = "10.1016/j.reprotox.2017.10.003",

language = "English",

volume = "74",

pages = "204--211",

journal = "Reproductive Toxicology",

issn = "0890-6238",

}

TY - JOUR

T1 - Tocopherol and selenite modulate the transplacental effects induced by sodium arsenite in hamsters

AU - Sampayo-Reyes, Adriana

AU - Taméz-Guerra, Reyes S.

AU - Bermúdez de León, Mario

AU - Vargas-Villarreal, Javier

AU - Lozano-Garza, Héctor Gerardo

AU - Rodríguez-Padilla, Cristina

AU - Cortés, Constanza

AU - Marcos, Ricard

AU - Hernández, Alba

PY - 2017/12/1

Y1 - 2017/12/1

N2 - © 2017 Elsevier Inc. Human studies suggest that in utero exposure to arsenic results in adverse pregnancy outcomes. The use of dietary supplements, such as sodium selenite (SS) or α-tocopherol succinate (α-TOS), is a reasonable approach to ameliorate such health effects. Sodium arsenite at 100 ppm was administered via drinking water to female hamsters from gestational days 1 or 8 to the time of delivery. Viable fetuses, fetal resorptions and non-viable fetuses were recorded during and after pregnancy and total arsenic and its metabolites were characterized in pregnant animals, placentas and fetuses. Arsenic was found to accumulate in the placenta and fetus, increasing fetal mortality, non-viable fetuses and resorptions. Co-administration of SS and α-TOS significantly reduced the observed teratogenic effects. SS influenced arsenic biotransformation by reducing the MMA/InAs index and increasing the DMA/MMA, whereas α-TOS more likely exerts its protective effect through its potent antioxidant activity.

AB - © 2017 Elsevier Inc. Human studies suggest that in utero exposure to arsenic results in adverse pregnancy outcomes. The use of dietary supplements, such as sodium selenite (SS) or α-tocopherol succinate (α-TOS), is a reasonable approach to ameliorate such health effects. Sodium arsenite at 100 ppm was administered via drinking water to female hamsters from gestational days 1 or 8 to the time of delivery. Viable fetuses, fetal resorptions and non-viable fetuses were recorded during and after pregnancy and total arsenic and its metabolites were characterized in pregnant animals, placentas and fetuses. Arsenic was found to accumulate in the placenta and fetus, increasing fetal mortality, non-viable fetuses and resorptions. Co-administration of SS and α-TOS significantly reduced the observed teratogenic effects. SS influenced arsenic biotransformation by reducing the MMA/InAs index and increasing the DMA/MMA, whereas α-TOS more likely exerts its protective effect through its potent antioxidant activity.

KW - Arsenic

KW - Hamster

KW - Selenium

KW - Teratogenesis

KW - Vitamin E

U2 - 10.1016/j.reprotox.2017.10.003

DO - 10.1016/j.reprotox.2017.10.003

M3 - Article

SN - 0890-6238

VL - 74

SP - 204

EP - 211

JO - Reproductive Toxicology

JF - Reproductive Toxicology

ER -

Tocopherol and selenite modulate the transplacental effects induced by sodium arsenite in hamsters

Abstract

Keywords

UN SDGs

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