To achieve an earlier IFN-γ response is not sufficient to control Mycobacterium tuberculosis infection in mice

Cristina Vilaplana, Clara Prats, Elena Marzo, Carles Barril, Marina Vegué, Jorge Diaz, Joaquim Valls, Daniel López, Pere Joan Cardona

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Abstract

The temporo-spatial relationship between the three organs (lung, spleen and lymph node) involved during the initial stages of Mycobacterium tuberculosis infection has been poorly studied. As such, we performed an experimental study to evaluate the bacillary load in each organ after aerosol or intravenous infection and developed a mathematical approach using the data obtained in order to extract conclusions. The results showed that higher bacillary doses result in an earlier IFN-γ response, that a certain bacillary load (BL) needs to be reached to trigger the IFN-γ response, and that control of the BL is not immediate after onset of the IFN-γ response, which might be a consequence of the spatial dimension. This study may have an important impact when it comes to designing new vaccine candidates as it suggests that triggering an earlier IFN-γ response might not guarantee good infection control, and therefore that additional properties should be considered for these candidates. © 2014 Vilaplana et al.
Original languageEnglish
Article numbere100830
JournalPLoS ONE
Volume9
Issue number6
DOIs
Publication statusPublished - 24 Jun 2014

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