Tissue macroarrays ("microchops") for gene expression analysis

PL Fernandez*, Iracema Nayach, E Fernandez, L Fresno, A Palacin, M. Farre, E Campo, A Cardesa

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)


We describe a simple system of tissue arraying with multiple tissue fragments obtained with a biopsy punch from selected areas of paraffin blocks. The new blocks thus constructed allow multiple tissue sections in which the uniform shape of the fragments coupled with a geometrical display and a significant amount of tissue per case allows a dependable, cost-effective way to screen tumors or other kinds of tissues with techniques such as immunohistochemistry. This system avoids the disadvantages of previous laborious methods of tissue arraying, such as expensive equipment and scarce tissue sampling, and it can be implemented in any institution with minimal cost and elaboration.

Original languageEnglish
Pages (from-to)591-594
Number of pages4
JournalVirchows Archiv
Issue number6
Publication statusPublished - Jun 2001


  • tissue array
  • immunohistochemistry
  • microchops


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