TY - JOUR
T1 - Tissue factor levels and high ratio of fibrinopeptide A: D-dimer as a measure of endothelial procoagulant disorder in pre-eclampsia
AU - Bellart, Jordi
AU - Gilabert, Rosa
AU - Anglès, Anna
AU - Piera, Veronica
AU - Miralles, Ramón M.
AU - Monasterio, Jasone
AU - Cabero, Lluis
PY - 1999/1/1
Y1 - 1999/1/1
N2 - To assess coagulation activation and endothelial cell injury in normotensive and pre-eclamptic pregnant women, a comparision was made of plama levels of tissue factor, fibronectin, fibrinopeptide A and D-dimer. Samples were taken from 50 nonpregnant women, 40 normotensive pregnant women in the third trimester and 27 women with pre-eclampsia after diagnosis and before treatment. High levels of fibrinopeptide A and D-dimer were found in pre-eclampsia women. Moreover, the ratio fibrinopeptide A:D-dimer was much greater in the pre-eclampsia group than in normotensive pregnant women. The levels of fibronectin and tissue factor were also higher in the pre-eclampsia group. The increase of tissue factor levels suggests an alteration of the extrinsir coagulation pathway in pre-eclampsia. The increase of fibrinopeptide A:D dimer ratio shows that the activation of coagulation is associated with a relative hypofibrinolysis in pre-eclampsia. © 1999 Blackwell Publishing Ltd.
AB - To assess coagulation activation and endothelial cell injury in normotensive and pre-eclamptic pregnant women, a comparision was made of plama levels of tissue factor, fibronectin, fibrinopeptide A and D-dimer. Samples were taken from 50 nonpregnant women, 40 normotensive pregnant women in the third trimester and 27 women with pre-eclampsia after diagnosis and before treatment. High levels of fibrinopeptide A and D-dimer were found in pre-eclampsia women. Moreover, the ratio fibrinopeptide A:D-dimer was much greater in the pre-eclampsia group than in normotensive pregnant women. The levels of fibronectin and tissue factor were also higher in the pre-eclampsia group. The increase of tissue factor levels suggests an alteration of the extrinsir coagulation pathway in pre-eclampsia. The increase of fibrinopeptide A:D dimer ratio shows that the activation of coagulation is associated with a relative hypofibrinolysis in pre-eclampsia. © 1999 Blackwell Publishing Ltd.
U2 - 10.1111/j.1471-0528.1999.tb08330.x
DO - 10.1111/j.1471-0528.1999.tb08330.x
M3 - Article
VL - 106
SP - 594
EP - 597
JO - BJOG: An International Journal of Obstetrics and Gynaecology
JF - BJOG: An International Journal of Obstetrics and Gynaecology
SN - 1470-0328
IS - 6
ER -