Tissue factor levels and high ratio of fibrinopeptide A: D-dimer as a measure of endothelial procoagulant disorder in pre-eclampsia

Jordi Bellart, Rosa Gilabert, Anna Anglès, Veronica Piera, Ramón M. Miralles, Jasone Monasterio, Lluis Cabero

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41 Citations (Scopus)

Abstract

To assess coagulation activation and endothelial cell injury in normotensive and pre-eclamptic pregnant women, a comparision was made of plama levels of tissue factor, fibronectin, fibrinopeptide A and D-dimer. Samples were taken from 50 nonpregnant women, 40 normotensive pregnant women in the third trimester and 27 women with pre-eclampsia after diagnosis and before treatment. High levels of fibrinopeptide A and D-dimer were found in pre-eclampsia women. Moreover, the ratio fibrinopeptide A:D-dimer was much greater in the pre-eclampsia group than in normotensive pregnant women. The levels of fibronectin and tissue factor were also higher in the pre-eclampsia group. The increase of tissue factor levels suggests an alteration of the extrinsir coagulation pathway in pre-eclampsia. The increase of fibrinopeptide A:D dimer ratio shows that the activation of coagulation is associated with a relative hypofibrinolysis in pre-eclampsia. © 1999 Blackwell Publishing Ltd.
Original languageEnglish
Pages (from-to)594-597
JournalBJOG: An International Journal of Obstetrics and Gynaecology
Volume106
Issue number6
DOIs
Publication statusPublished - 1 Jan 1999

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