Previous data from our laboratory have demonstrated that luteinizing hormone and prolactin responses to stress were depressed in peripuberal (50-60 days old) compared with adult (approximately 100 days old) rats. Then we decided to study the secretion of thyrotropin at both ages. Our results indicate that neither thyrotropin response to acute restraint stress nor pituitary response to TRH administration differed in peripuberal and adult male rats. As there is some evidence suggesting a role for endogenous opiates in stress-induced inhibition of thyrotropin, the thyrotropin response to morphine administration was tested. Again morphine-induced inhibition of thyrotropin was not influenced by age. It is concluded that regulation of thyrotropin secretion, unlike that of LH and prolactin appears to be very similar in peripuberal and adult rats.
|Publication status||Published - 1 Jan 1985|