Projects per year
The molecular mechanism of temperature-dependent sex determination (TSD) is a long-standing mystery. How is the thermal signal sensed, captured and transduced to regulate key sex genes? Although there is compelling evidence for pathways via which cells capture the temperature signal, there is no known mechanism by which cells transduce those thermal signals to affect gene expression. Here we propose a novel hypothesis we call 3D-TSD (the three dimensions of thermolabile sex determination). We postulate that the genome has capacity to remodel in response to temperature by changing 3D chromatin conformation, perhaps via temperature-sensitive transcriptional condensates. This could rewire enhancer–promoter interactions to alter the expression of key sex-determining genes. This hypothesis can accommodate monogenic or multigenic thermolabile sex-determining systems, and could be combined with upstream thermal sensing and transduction to the epigenome to commit gonadal fate.
- Promoter Regions, Genetic
- Sex Determination Processes/genetics
- Sex Ratio
FingerprintDive into the research topics of 'Three dimensions of thermolabile sex determination'. Together they form a unique fingerprint.
- 1 Active
Ruiz Herrera Moreno, A. M., Garcia Haro, F., Marín Gual, L., Deakin, J., Farré Belmonte, M., ROBINSON, T., Sanseverino, W., WATERS, P., Pujol i Infantes, G., Marin Garcia, C., Gonzalez Rodelas, L. & Ruiz Herrera Moreno, A. M.
1/09/21 → 31/08/25
Project: Research Projects and Other Grants