Thirty-two new cases with small supernumerary marker chromosomes detected in connection with fertility problems: Detailed molecular cytogenetic characterization and review of the literature

Marina Manvelyan, Mariluce Riegel, Monica Santos, Carme Fuster, Franck Pellestor, Marie Luise Mazaurik, Bernt Schulze, Anna Polityko, Hanne Tittelbach, Gisela Reising-Ackermann, Britta Belitz, Ute Hehr, Christina Kelbova, Marianne Volleth, Elisabeth Gödde, Jasen Anderson, Peter Küpferling, Sigrid Köhler, Hans Christoph Duba, Andreas DufkeDilek Aktas, Thomas Martin, Isolde Schreyer, Elisabeth Ewers, Daniela Reich, Kristin Mrasek, Anja Weise, Thomas Liehr

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40 Citations (Scopus)

Abstract

Thirty-two patients with fertility problems were identified as carriers of small supernumerary marker chromosomes (sSMC). Molecular cytogenetic techniques were used other characterize their chromosomal origin. Together with the other cases available in the literature 111 sSMC cases have now been detected in connection with fertility problems in otherwise clinically healthy persons and characterized for their genetic content. According to this study, in 60% of the cases the sSMC originated from chromosomes 14 or 15. Euchromatic imbalances were caused by the sSMC presence in 30% of the cases. Notably, in 53% of infertile sSMC carriers, the sSMC was parentally transmitted. As we found indications of an as yet unknown mechanism for the elimination of sSMC from the human gene pool, sSMC could also play a role in elucidating the process of chromosome gain and loss during evolution. Nonetheless, further detailed molecular analysis will be necessary in the future to characterize the mechanisms and genetic basis for this phenomenon.
Original languageEnglish
Pages (from-to)705-714
JournalInternational Journal of Molecular Medicine
Volume21
Issue number6
Publication statusPublished - 1 Jun 2008

Keywords

  • De novo
  • Euchromatic variations
  • Familial
  • Fertility problems
  • Molecular cytogenetics
  • Small supernumerary marker chromosomes

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