Thioflavin-T excimer formation upon interaction with amyloid fibers

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Abstract

The molecular mechanism of the Thioflavin-T (Th-T) binding to amyloids remains unknown. By combining experimental analysis of Th-T excitation and emission spectra with theoretical calculations we suggest that Th-T fluorescence changes upon interaction with amyloids may arise from the formation of an excimer with an oblique angle of ∼120 degrees. © 2013 The Royal Society of Chemistry.
Original languageEnglish
Pages (from-to)5745-5747
JournalChemical Communications
Volume49
Issue number51
DOIs
Publication statusPublished - 28 Jun 2013

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