The molecular mechanism of the Thioflavin-T (Th-T) binding to amyloids remains unknown. By combining experimental analysis of Th-T excitation and emission spectra with theoretical calculations we suggest that Th-T fluorescence changes upon interaction with amyloids may arise from the formation of an excimer with an oblique angle of ∼120 degrees. © 2013 The Royal Society of Chemistry.
|Publication status||Published - 28 Jun 2013|
Sabate, R., Rodriguez-Santiago, L., Sodupe, M., Saupe, S. J., & Ventura, S. (2013). Thioflavin-T excimer formation upon interaction with amyloid fibers. Chemical Communications, 49(51), 5745-5747. https://doi.org/10.1039/c3cc42040j