Therapeutic management and comorbidities in opiate-dependent patients undergoing a replacement therapy programme in Spain: The PROTEUS study

Carlos Roncero, Gideoni Fuste, Carmen Barral, Laia Rodríguez-Cintas, Nieves Martínez-Luna, Francisco José Eiroa-Orosa, Miguel Casas

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26 Citations (Scopus)

Abstract

© 2011, Pacini Editore S.p.A. All rights reserved. The aim of this study was to comprehensively describe the clinical comorbidities, concomitant treatments and the current therapeutic management of opiate-dependent patients undergoing a replacement therapy programme (RTP). This is an observational, cross-sectional, multicentre, epidemiological study conducted in 74 healthcare centres for drug users. Patients were diagnosed with Opiate Dependence (OD), and enrolled in a RTP in Spain (N=624). Most patients were men (84%); they received methadone (94%) at a mean dose of 61.52mg/day during the maintenance phase, orally (95%) with take-home doses (76%). High rates of infectious (59%) and psychiatric comorbidities (67%) were found. Patients infected by HIV, HCV or coinfected by HIV/HCV were given significantly higher methadone doses (p<0.0001).
Original languageEnglish
Pages (from-to)5-16
JournalHeroin Addiction and Related Clinical Problems
Volume13
Issue number3
Publication statusPublished - 1 Sep 2011

Keywords

  • Infectious comorbidites
  • Opiate dependence
  • Psychiatric comorbidities
  • Replacement therapies
  • Therapeutic management

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