Theoretical study on the mechanism of iron carbonyls mediated isomerization of allylic alcohols to saturated carbonyls

Vicenç Branchadell, Christophe Crévisy, René Grée

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34 Citations (Scopus)

Abstract

Abstract: The conversion of allylic alcohols to enols mediated by Fe(CO)3 has been studied through density functional theoretical calculations. From the results obtained a complete catalytic cycle has been proposed in which the first intermediate is the [(allyl alcohol)Fe(CO)3] complex. This intermediate evolves to the [(enol)Fe(CO)3] complex through two consecutive 1,3-hydrogen shifts involving a π-allyl hydride intermediate. The highest Gibbs energy transition state corresponds to the partial decoordination ot the enol ligand prior to the coordination of a new allyl alcohol molecule that regenerates the first intermediate. Alternative processes for the [(enol)Fe(CO)3] complex such as [Fe (CO)3]-mediated enol-aldehyde transformation and enol isomerization have also been considered. The results obtained show that the former process is unfavourable, whereas the enol isomerization may compete with the enol decoordination step of the catalytic cycle.
Original languageEnglish
Pages (from-to)2062-2067
JournalChemistry - A European Journal
Volume9
Issue number9
DOIs
Publication statusPublished - 9 May 2003

Keywords

  • Allylic compounds
  • Density functional calculations
  • Homogeneous catalysis
  • Iron carbonyls
  • Isomerization

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