The wing-spot and the comet tests as useful assays detecting genotoxicity in Drosophila

Ricard Marcos, Erico R. Carmona

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Abstract

In spite of its pioneer use in detecting mutational processes, Drosophila has yet an important role in studies aiming to detect and quantify the induction of DNA damage. Here we describe two assays, one detecting primary damage (the Comet assay) and the other detecting somatic mutation and recombination effects (wing-spot test). It is important to emphasize that somatic recombination is a key event in cancer and no assays exist to detect and quantify somatic recombination processes, other than the spot tests developed in Drosophila. © Springer Science+Business Media, New York 2013.
Original languageEnglish
Pages (from-to)417-427
JournalMethods in Molecular Biology
Volume1044
DOIs
Publication statusPublished - 1 Jan 2013

Keywords

  • Comet assay
  • DNA damage
  • Drosophila
  • Genotoxicity
  • Wing-spot test

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