The weaver gene has no effect on the generation patterns of mesencephalic dopaminergic neurons

Joaquín Martí, Katherine V. Wills, Bernardino Ghetti, Shirley A. Bayer

    Research output: Contribution to journalArticleResearchpeer-review

    8 Citations (Scopus)

    Abstract

    To determine if the weaver gene has action on late-generated neurons in midbrain areas on postnatal day (P) 8 [3H] thymidine autoradiography and tyrosine hydroxylase immunohistochemistry were combined in the same tissue section in homozygous weaver mice and normal controls. The experimental animals were the offspring of pregnant dams injected with [3H] thymidine on embryonic days (E) 11-12, E12-13, E13-14 and E14-15. Both the span of neurogenesis and the neurogenetic timetables of dopaminergic neurons were similar between wild-type and homozygous weavers in all midbrain areas analyzed. No loss of late-generated dopaminergic neurons was observed. The cytoarchitecture of the midbrain dopaminergic cell groups were also the same in both experimental groups indicating that cell migration, settling, and cytodifferentiation proceeds normally in spite of the presence of the weaver gene. (C) 2000 Elsevier Science B.V.
    Original languageEnglish
    Pages (from-to)165-172
    JournalDevelopmental Brain Research
    Volume122
    Issue number2
    DOIs
    Publication statusPublished - 30 Aug 2000

    Keywords

    • Dopaminergic neuron loss
    • Interfascicular nucleus
    • Retrorubral field
    • Substantia nigra pars compacta
    • Tyrosine hydroxylase immunohistochemistry
    • Ventral tegmental area
    • Weaver mutant mouse
    • [ H] Thymidine autoradiography 3

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