The weaver gene has no effect on the generation patterns of mesencephalic dopaminergic neurons

Joaquín Martí; Katherine V. Wills; Bernardino Ghetti; Shirley A. Bayer

doi:10.1016/S0165-3806(00)00070-5

The weaver gene has no effect on the generation patterns of mesencephalic dopaminergic neurons

Joaquín Martí, Katherine V. Wills, Bernardino Ghetti, Shirley A. Bayer

Research output: Contribution to journal › Article › Research › peer-review

8 Citations (Scopus)

Abstract

To determine if the weaver gene has action on late-generated neurons in midbrain areas on postnatal day (P) 8 [3H] thymidine autoradiography and tyrosine hydroxylase immunohistochemistry were combined in the same tissue section in homozygous weaver mice and normal controls. The experimental animals were the offspring of pregnant dams injected with [3H] thymidine on embryonic days (E) 11-12, E12-13, E13-14 and E14-15. Both the span of neurogenesis and the neurogenetic timetables of dopaminergic neurons were similar between wild-type and homozygous weavers in all midbrain areas analyzed. No loss of late-generated dopaminergic neurons was observed. The cytoarchitecture of the midbrain dopaminergic cell groups were also the same in both experimental groups indicating that cell migration, settling, and cytodifferentiation proceeds normally in spite of the presence of the weaver gene. (C) 2000 Elsevier Science B.V.

Original language	English
Pages (from-to)	165-172
Journal	Developmental Brain Research
Volume	122
Issue number	2
DOIs	https://doi.org/10.1016/S0165-3806(00)00070-5
Publication status	Published - 30 Aug 2000

Keywords

Dopaminergic neuron loss
Interfascicular nucleus
Retrorubral field
Substantia nigra pars compacta
Tyrosine hydroxylase immunohistochemistry
Ventral tegmental area
Weaver mutant mouse
[ H] Thymidine autoradiography 3

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title = "The weaver gene has no effect on the generation patterns of mesencephalic dopaminergic neurons",

abstract = "To determine if the weaver gene has action on late-generated neurons in midbrain areas on postnatal day (P) 8 [3H] thymidine autoradiography and tyrosine hydroxylase immunohistochemistry were combined in the same tissue section in homozygous weaver mice and normal controls. The experimental animals were the offspring of pregnant dams injected with [3H] thymidine on embryonic days (E) 11-12, E12-13, E13-14 and E14-15. Both the span of neurogenesis and the neurogenetic timetables of dopaminergic neurons were similar between wild-type and homozygous weavers in all midbrain areas analyzed. No loss of late-generated dopaminergic neurons was observed. The cytoarchitecture of the midbrain dopaminergic cell groups were also the same in both experimental groups indicating that cell migration, settling, and cytodifferentiation proceeds normally in spite of the presence of the weaver gene. (C) 2000 Elsevier Science B.V.",

keywords = "Dopaminergic neuron loss, Interfascicular nucleus, Retrorubral field, Substantia nigra pars compacta, Tyrosine hydroxylase immunohistochemistry, Ventral tegmental area, Weaver mutant mouse, [ H] Thymidine autoradiography 3",

author = "Joaqu{\'i}n Mart{\'i} and Wills, {Katherine V.} and Bernardino Ghetti and Bayer, {Shirley A.}",

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T1 - The weaver gene has no effect on the generation patterns of mesencephalic dopaminergic neurons

AU - Martí, Joaquín

AU - Wills, Katherine V.

AU - Ghetti, Bernardino

AU - Bayer, Shirley A.

PY - 2000/8/30

Y1 - 2000/8/30

N2 - To determine if the weaver gene has action on late-generated neurons in midbrain areas on postnatal day (P) 8 [3H] thymidine autoradiography and tyrosine hydroxylase immunohistochemistry were combined in the same tissue section in homozygous weaver mice and normal controls. The experimental animals were the offspring of pregnant dams injected with [3H] thymidine on embryonic days (E) 11-12, E12-13, E13-14 and E14-15. Both the span of neurogenesis and the neurogenetic timetables of dopaminergic neurons were similar between wild-type and homozygous weavers in all midbrain areas analyzed. No loss of late-generated dopaminergic neurons was observed. The cytoarchitecture of the midbrain dopaminergic cell groups were also the same in both experimental groups indicating that cell migration, settling, and cytodifferentiation proceeds normally in spite of the presence of the weaver gene. (C) 2000 Elsevier Science B.V.

AB - To determine if the weaver gene has action on late-generated neurons in midbrain areas on postnatal day (P) 8 [3H] thymidine autoradiography and tyrosine hydroxylase immunohistochemistry were combined in the same tissue section in homozygous weaver mice and normal controls. The experimental animals were the offspring of pregnant dams injected with [3H] thymidine on embryonic days (E) 11-12, E12-13, E13-14 and E14-15. Both the span of neurogenesis and the neurogenetic timetables of dopaminergic neurons were similar between wild-type and homozygous weavers in all midbrain areas analyzed. No loss of late-generated dopaminergic neurons was observed. The cytoarchitecture of the midbrain dopaminergic cell groups were also the same in both experimental groups indicating that cell migration, settling, and cytodifferentiation proceeds normally in spite of the presence of the weaver gene. (C) 2000 Elsevier Science B.V.

KW - Dopaminergic neuron loss

KW - Interfascicular nucleus

KW - Retrorubral field

KW - Substantia nigra pars compacta

KW - Tyrosine hydroxylase immunohistochemistry

KW - Ventral tegmental area

KW - Weaver mutant mouse

KW - [ H] Thymidine autoradiography 3

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DO - 10.1016/S0165-3806(00)00070-5

M3 - Article

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SP - 165

EP - 172

IS - 2

ER -

The weaver gene has no effect on the generation patterns of mesencephalic dopaminergic neurons

Abstract

Keywords

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