The utility of serology in diagnosing candidosis in non-neutropenic critically ill patients

J. Ibàñez-Nolla, J. M. Torres-Rodrguez, M. Nolla, M. A. León, R. Mèndez, G. Soria, R. M. Díaz, J. Marrugat

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This study was carried out to evaluate the utility of serological tests in the diagnosis of candidal infections in non-neutropenic critically ill patients. A prospective study was carried out in a 10-bed general intensive care unit; all patients with at least one organic sample with Candida spp. were included. A therapeutic-diagnostic algorithm was designed, and patients were treated or not, according to a classification. Blood samples were taken, and serological tests included: Antigenaemia detection using two different commercial latex kits (Cand-Tec® and Pastorex®) and antibody detection by indirect haemagglutination (IHA) and indirect germ tube immunofluorescence (IFA). A total of 56% of antibody tests (IHA 45% and IFA 64%) and 26% of antigen tests (Cand-Tec 36% and Pastorex 17%) were positive. The sensitivity and specificity of these tests with respect to systemic candidosis were 37% and 78%, respectively, for antibodies, and 0% and 90% for antigens. There was statistical significance for mortality and low levels of antibodies; Candida glabrata was detected by IFA and Candida tropicalis by Cand-Tec. Serological tests may help to define the prognosis of these patients and to support the detection of specific Candida species.
Original languageEnglish
Pages (from-to)47-53
Publication statusPublished - 21 May 2001


  • Candida glabrata
  • Candidosis
  • ICU
  • Non-neutropenic
  • Serology


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