The up-regulation profiles of p21WAF1/CIP1 and RUNX1/AML1 correlate with myometrial infiltration in endometrioid endometrial carcinoma

Jesús Planagumà, Marta Gonzalez, Andreas Doll, Marta Monge, Antonio Gil-Moreno, Teresa Baró, Angel García, Jordi Xercavins, Francesc Alameda, Miguel Abal, Jaume Reventós

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18 Citations (Scopus)


We have recently described RUNX1/AML1 up-regulation in endometrioid endometrial carcinoma (EEC), proposing that it could play a role during the initial steps of myometrial infiltration. Some cell cycle regulators, including the cyclin-dependent kinase inhibitor p21WAF1/CIP1, have been described as targets of RUNX1/AML1. In this study, we have attempted to address the question of whether RUNX1/AML1, acting both as a gene transcription activator and a repressor, depending on the context, can be correlated with the expression of p21WAF1/CIP1 in gynecologic malignancies, in particular in EEC, where the role of p21WAF1/CIP1 remains controversial. Toward this end, we analyzed p21WAF1/CIP1 expression in a large panel of EEC samples using real-time quantitative polymerase chain reaction and tissue microarray immunohistochemistry, and evaluated the extent to which RUNX1/AML1 and p21WAF1/CIP1 interacted in the EEC samples. The strong correlation found between RUNX1/AML1 and p21WAF1/CIP1 suggested cooperation between the 2 genes in EEC, especially in those tumor samples corresponding to stage IC carcinomas, infiltrating more than 50% of the myometrium. We hypothesize that p21WAF1/CIP1 and RUNX1/AML1 interact during the initial steps of tumor dissemination in EEC, and we discuss mechanisms that could underlie myometrial infiltration and/or the promotion of an invasive phenotype. © 2006.
Original languageEnglish
Pages (from-to)1050-1057
JournalHuman Pathology
Issue number8
Publication statusPublished - 1 Aug 2006


  • Cell cycle alterations
  • Endometrioid endometrial carcinoma
  • Myometrial infiltration
  • p21 WAF1/CIP1
  • RUNX1/AML1


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